Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.kint.2016.12.024 http://scihub22266oqcxt.onion/10.1016/j.kint.2016.12.024 C5930006!5930006!28274484     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Int 2017 ; 92 (1): 201-13 Nephropedia Template TP {{tp|p=28274484|t=2017. Post-transplant peripheral blood donor-specific IFN-? ELISPOT assays differentiates risk of subclinical rejection and de novo donor-specific alloantibodies in kidney transplant recipients |pdf=|usr=}}{{28274484}} gab.com Text Post-transplant peripheral blood donor-specific IFN- ELISPOT assays differentiates risk of subclinical rejection and de novo donor-specific alloantibodies in kidney transplant recipients JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=28274484 #FOAvip Noninvasive diagnosis of kidney allograft inflammation in transplant recipients with stable graft function (subclinical rejection) could permit more effective therapy and prevent later development of de novo anti-donor HLA antibodies and/or graft dysfunction. Here we tested whether quantifying post-transplant donor-specific alloreactive T cells by IFN-? ELISPOT assay noninvasively detects subclinical T-cell mediated rejection and/or predicts development of anti-donor HLA antibodies. Using an initial cross-sectional cohort of 60 kidney transplant patients with six-month surveillance biopsies, we found that negative ELISPOT assays accurately ruled out the presence of subclinical T cell mediated rejection. These results were validated using a distinct prospective cohort of 101 patients where donor specific IFN-? ELISPOT results at both three- and six-months post-transplant significantly differentiated patients with subclinical T cell mediated rejection at six-month, independent of other clinical variables (odds ratio 0.072, 95% confidence interval 0.008-0.653). The post-transplant donor-specific IFN-? ELISPOT results independently associated with subsequent development of significant anti-donor HLA antibodies (0.085, 0.008-0.862) and with significantly worse two-year function (estimated glomerular filtration rate) compared to patients with a negative test. Thus, post-transplant immune monitoring by donor-specific IFN-? ELISPOT can assess risk for developing subclinical T cell mediated rejection and anti-donor HLA antibodies, potentially limiting the need for surveillance biopsies. Our study provides a guide for individualizing immunosuppression to improve post-transplant outcomes. Twit Text FOAVip Post-transplant peripheral blood donor-specific IFN- ELISPOT assays differentiates risk of subclinical rejection and de novo donor-specific alloantibodies in kidney transplant recipients ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=28274484 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28274484 #FOAvip English Wikipedia <ref>{{Cite pmid|28274484}}</ref> Post-transplant peripheral blood donor-specific IFN-? ELISPOT assays differentiates risk of subclinical rejection and de novo donor-specific alloantibodies in kidney transplant recipients #MMPMID28274484 Crespo E; Cravedi P; Martorell J; Luque S; Melilli E; Cruzado JM; Jarque M; Meneghini M; Manonelles A; Donadei C; Lloberas N; Gomà M; Grinyó JM; Heeger P; Bestard O Kidney Int 2017[Jul]; 92 (1): 201-13 PMID28274484show ga Noninvasive diagnosis of kidney allograft inflammation in transplant recipients with stable graft function (subclinical rejection) could permit more effective therapy and prevent later development of de novo anti-donor HLA antibodies and/or graft dysfunction. Here we tested whether quantifying post-transplant donor-specific alloreactive T cells by IFN-? ELISPOT assay noninvasively detects subclinical T-cell mediated rejection and/or predicts development of anti-donor HLA antibodies. Using an initial cross-sectional cohort of 60 kidney transplant patients with six-month surveillance biopsies, we found that negative ELISPOT assays accurately ruled out the presence of subclinical T cell mediated rejection. These results were validated using a distinct prospective cohort of 101 patients where donor specific IFN-? ELISPOT results at both three- and six-months post-transplant significantly differentiated patients with subclinical T cell mediated rejection at six-month, independent of other clinical variables (odds ratio 0.072, 95% confidence interval 0.008-0.653). The post-transplant donor-specific IFN-? ELISPOT results independently associated with subsequent development of significant anti-donor HLA antibodies (0.085, 0.008-0.862) and with significantly worse two-year function (estimated glomerular filtration rate) compared to patients with a negative test. Thus, post-transplant immune monitoring by donor-specific IFN-? ELISPOT can assess risk for developing subclinical T cell mediated rejection and anti-donor HLA antibodies, potentially limiting the need for surveillance biopsies. Our study provides a guide for individualizing immunosuppression to improve post-transplant outcomes. äPost-transplant peripheral blood donor-specific IFN-? ELISPOT assays d(epmc).pdf DeepDyve Pubget Overpricing