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10.1002/2211-5463.12421 http://scihub22266oqcxt.onion/10.1002/2211-5463.12421 C5929927!5929927!29744297     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+Open+Bio 2018 ; 8 (5): 836-42 Nephropedia Template TP {{tp|p=29744297|t=2018. FGF?2 suppresses expression of nephronectin via JNK and PI3K pathways |pdf=|usr=}}{{29744297}} gab.com Text FGF 2 suppresses expression of nephronectin via JNK and PI3K pathways JO: FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=29744297 #FOAvip Nephronectin (Npnt), an extracellular matrix protein, is a ligand for integrin ?8?1 and is involved in the development of various organs, such as the kidneys, bones, liver, and muscles. Previously, we found that Npnt expression was inhibited by various cytokines including transforming growth factor?? (Tgf??) and oncostatin M (Osm). Fibroblast growth factor (Fgf)?2, otherwise known as basic Fgf, also plays important roles in skeletal development and postnatal osteogenesis. In this study, Npnt expression was found to be suppressed by Fgf?2 in MC3T3?E1 cells, an osteoblast?like cell line, in a dose? and time?dependent manners. Furthermore, Fgf?2?mediated NpntmRNA suppression was shown to involve the Jun N?terminal kinase (JNK) and phosphoinositide?3 kinase (PI3K) pathways. Together, our results suggest that FGF?2 suppresses Npnt gene expression via JNK and PI3K pathways. Twit Text FOAVip FGF 2 suppresses expression of nephronectin via JNK and PI3K pathways ????FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=29744297 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29744297 #FOAvip English Wikipedia <ref>{{Cite pmid|29744297}}</ref> FGF?2 suppresses expression of nephronectin via JNK and PI3K pathways #MMPMID29744297 Kato T; Yamada A; Ikehata M; Yoshida Y; Sasa K; Morimura N; Sakashita A; Iijima T; Chikazu D; Ogata H; Kamijo R FEBS Open Bio 2018[May]; 8 (5): 836-42 PMID29744297show ga Nephronectin (Npnt), an extracellular matrix protein, is a ligand for integrin ?8?1 and is involved in the development of various organs, such as the kidneys, bones, liver, and muscles. Previously, we found that Npnt expression was inhibited by various cytokines including transforming growth factor?? (Tgf??) and oncostatin M (Osm). Fibroblast growth factor (Fgf)?2, otherwise known as basic Fgf, also plays important roles in skeletal development and postnatal osteogenesis. In this study, Npnt expression was found to be suppressed by Fgf?2 in MC3T3?E1 cells, an osteoblast?like cell line, in a dose? and time?dependent manners. Furthermore, Fgf?2?mediated NpntmRNA suppression was shown to involve the Jun N?terminal kinase (JNK) and phosphoinositide?3 kinase (PI3K) pathways. Together, our results suggest that FGF?2 suppresses Npnt gene expression via JNK and PI3K pathways. äFGF?2 suppresses expression of nephronectin via JNK and PI3K pathways (epmc).pdf DeepDyve Pubget Overpricing