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2018 ; 58
(4
): 164-172
Nephropedia Template TP
gab.com Text
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English Wikipedia
Efficacy and Safety of REVIVE SE Thrombectomy Device for Acute Ischemic Stroke:
River JAPAN (Reperfuse Ischemic Vessels with Endovascular Recanalization Device
in Japan)
#MMPMID29526881
Sakai N
; Ota S
; Matsumoto Y
; Kondo R
; Satow T
; Kubo M
; Tsumoto T
; Enomoto Y
; Kataoka T
; Imamura H
; Todo K
; Hayakawa M
; Yamagami H
; Toyoda K
; Ito Y
; Sugiu K
; Matsumaru Y
; Yoshimura S
Neurol Med Chir (Tokyo)
2018[Apr]; 58
(4
): 164-172
PMID29526881
show ga
REVIVE SE (REVIVE) is a closed-ended, self-expanding stent retriever used in the
RIVER JAPAN study. We present our early experience with REVIVE for
revascularization of acute ischemic stroke (AIS) in patients who have failed or
are ineligible for intravenous recombinant tissue plasminogen activator
treatment. This prospective, single-arm, non-randomized, multicenter registry
study followed up patients undergoing mechanical thrombectomy with REVIVE for 90
days. The primary endpoint was a post-procedure Thrombolysis in Cerebral
Infarction (TICI) score ?2a. Secondary endpoints were clot
migration/embolization; recanalization without symptomatic intracranial
hemorrhage (ICH) at 24 h; symptomatic ICH; good neurological outcome (modified
Rankin Scale score ?2 National Institute of Health Stroke Scale (NIHSS) score
decrease ?10) at day 90; device- or procedure-related serious adverse events
(SAEs) and mortality at day 90. To confirm non-inferiority of REVIVE, results
were compared with historical data of the Merci Retriever. About 49 patients were
enrolled (median age 73 years; males 46.9%; middle cerebral artery (MCA)
occlusion 83.7%; median NIHSS score 17). A post-procedure TICI score ?2a was
observed in 73.5% (36/49, 95% confidence interval [CI] 58.9-85.1) of patients. No
post-procedural clot migration/embolization events occurred. Successful
recanalization without symptomatic ICH was observed in 62.5% (30/48, 95% CI
47.4-76.0). The good neurological outcome was achieved in 66.7% (32/48) patients.
Symptomatic ICH and device- or procedure-related SAEs were reported in 6.3% and
12.2% of patients, respectively. Two deaths were reported. REVIVE demonstrated
equivalent efficacy and safety as the Merci Retriever. Results suggest that
REVIVE is effective and safe in recanalizing occluded intracranial arteries in
AIS.