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10.1371/journal.ppat.1006985 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1006985 C5929570!5929570 !29672594     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29672594 &cmd=llinks): Failed to open stream: HTTP request failed! 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Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment |pdf=|usr=}}{{29672594 }} gab.com Text Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=29672594 #FOAvip Regulatory T cells (Tregs) play a cardinal role in the immune system by suppressing detrimental autoimmune responses, but their role in acute, chronic infectious diseases and tumor microenvironment remains unclear. We recently demonstrated that IFN-?/? receptor (IFNAR) signaling promotes Treg function in autoimmunity. Here we dissected the functional role of IFNAR-signaling in Tregs using Treg-specific IFNAR deficient (IFNARfl/flxFoxp3YFP-Cre) mice in acute LCMV Armstrong, chronic Clone-13 viral infection, and in tumor models. In both viral infection and tumor models, IFNARfl/flxFoxp3YFP-Cre mice Tregs expressed enhanced Treg associated activation antigens. LCMV-specific CD8+ T cells and tumor infiltrating lymphocytes from IFNARfl/flxFoxp3YFP-Cre mice produced less antiviral and antitumor IFN-? and TNF-?. In chronic viral model, the numbers of antiviral effector and memory CD8+ T cells were decreased in IFNARfl/flxFoxp3YFP-Cre mice and the effector CD4+ and CD8+ T cells exhibited a phenotype compatible with enhanced exhaustion. IFNARfl/flxFoxp3YFP-Cre mice cleared Armstrong infection normally, but had higher viral titers in sera, kidneys and lungs during chronic infection, and higher tumor burden than the WT controls. The enhanced activated phenotype was evident through transcriptome analysis of IFNARfl/flxFoxp3YFP-Cre mice Tregs during infection demonstrated differential expression of a unique gene signature characterized by elevated levels of genes involved in suppression and decreased levels of genes mediating apoptosis. Thus, IFN signaling in Tregs is beneficial to host resulting in a more effective antiviral response and augmented antitumor immunity. Twit Text FOAVip Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=29672594 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29672594 #FOAvip English Wikipedia <ref>{{Cite pmid|29672594 }}</ref> Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment #MMPMID29672594 Gangaplara A ; Martens C ; Dahlstrom E ; Metidji A ; Gokhale AS ; Glass DD ; Lopez-Ocasio M ; Baur R ; Kanakabandi K ; Porcella SF ; Shevach EM PLoS Pathog 2018[Apr]; 14 (4 ): e1006985 PMID29672594 show ga Regulatory T cells (Tregs) play a cardinal role in the immune system by suppressing detrimental autoimmune responses, but their role in acute, chronic infectious diseases and tumor microenvironment remains unclear. We recently demonstrated that IFN-?/? receptor (IFNAR) signaling promotes Treg function in autoimmunity. Here we dissected the functional role of IFNAR-signaling in Tregs using Treg-specific IFNAR deficient (IFNARfl/flxFoxp3YFP-Cre) mice in acute LCMV Armstrong, chronic Clone-13 viral infection, and in tumor models. In both viral infection and tumor models, IFNARfl/flxFoxp3YFP-Cre mice Tregs expressed enhanced Treg associated activation antigens. LCMV-specific CD8+ T cells and tumor infiltrating lymphocytes from IFNARfl/flxFoxp3YFP-Cre mice produced less antiviral and antitumor IFN-? and TNF-?. In chronic viral model, the numbers of antiviral effector and memory CD8+ T cells were decreased in IFNARfl/flxFoxp3YFP-Cre mice and the effector CD4+ and CD8+ T cells exhibited a phenotype compatible with enhanced exhaustion. IFNARfl/flxFoxp3YFP-Cre mice cleared Armstrong infection normally, but had higher viral titers in sera, kidneys and lungs during chronic infection, and higher tumor burden than the WT controls. The enhanced activated phenotype was evident through transcriptome analysis of IFNARfl/flxFoxp3YFP-Cre mice Tregs during infection demonstrated differential expression of a unique gene signature characterized by elevated levels of genes involved in suppression and decreased levels of genes mediating apoptosis. Thus, IFN signaling in Tregs is beneficial to host resulting in a more effective antiviral response and augmented antitumor immunity. |Animals [MESH] |Antiviral Agents/pharmacology [MESH] |Arenaviridae Infections/drug therapy/*immunology/metabolism/virology [MESH] |CD8-Positive T-Lymphocytes/drug effects/immunology/metabolism [MESH] |Cells, Cultured [MESH] |Colonic Neoplasms/drug therapy/*immunology/metabolism/virology [MESH] |Immunity, Innate/drug effects/immunology [MESH] |Interferon Type I/*pharmacology [MESH] |Interferon-gamma/metabolism [MESH] |Lymphocytic Choriomeningitis/drug therapy/*immunology/metabolism/virology [MESH] |Lymphocytic choriomeningitis virus/drug effects [MESH] |Melanoma, Experimental/drug therapy/*immunology/metabolism/virology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Receptor, Interferon alpha-beta/physiology [MESH] |Signal Transduction/drug effects [MESH] |T-Lymphocytes, Regulatory/drug effects/*immunology/metabolism/virology [MESH]Type I interferon signaling attenuates regulatory T cell function in v(epmc).pdf DeepDyve Pubget Overpricing