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2018 ; 13
(5
): e0196588
Nephropedia Template TP
gab.com Text
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English Wikipedia
FusionHub: A unified web platform for annotation and visualization of gene fusion
events in human cancer
#MMPMID29715310
Panigrahi P
; Jere A
; Anamika K
PLoS One
2018[]; 13
(5
): e0196588
PMID29715310
show ga
Gene fusion is a chromosomal rearrangement event which plays a significant role
in cancer due to the oncogenic potential of the chimeric protein generated
through fusions. At present many databases are available in public domain which
provides detailed information about known gene fusion events and their functional
role. Existing gene fusion detection tools, based on analysis of transcriptomics
data usually report a large number of fusion genes as potential candidates, which
could be either known or novel or false positives. Manual annotation of these
putative genes is indeed time-consuming. We have developed a web platform
FusionHub, which acts as integrated search engine interfacing various fusion gene
databases and simplifies large scale annotation of fusion genes in a seamless
way. In addition, FusionHub provides three ways of visualizing fusion events:
circular view, domain architecture view and network view. Design of potential
siRNA molecules through ensemble method is another utility integrated in
FusionHub that could aid in siRNA-based targeted therapy. FusionHub is freely
available at https://fusionhub.persistent.co.in.