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2018 ; 9
(28
): 19481-19489
Nephropedia Template TP
gab.com Text
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English Wikipedia
Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in
response to staphylococcal enterotoxin
#MMPMID29731960
Woetmann A
; Alhede M
; Dabelsteen S
; Bjarnsholt T
; Rybtke M
; Nastasi C
; Krejsgaard T
; Andersen MH
; Bonefeld CM
; Geisler C
; Givskov M
; Odum N
Oncotarget
2018[Apr]; 9
(28
): 19481-19489
PMID29731960
show ga
Anti-microbial peptides are produced at outer and inner surfaces by epithelia and
innate immune cells in response to bacterial infection. Staphylococcus aureus is
an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft
tissue infections and life-threatening bacteremia and sepsis. Here we show that
(i) skin T cells in chronic wounds infected with S. aureus express interleukin-26
(IL-26) in situ, (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression
in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and
inhibits biofilm formation and growth of S. aureus. Thus, we provide novel
evidence that IL-26 is an anti-microbial peptide produced by T cells in response
to SE. Accordingly, we propose that IL-26 producing T cells take part in the
innate immune response to SE producing S. aureus and thus play a novel role in
the primary innate immune defense in addition to their classical role in adaptive
immunity.