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10.18632/oncotarget.24603

http://scihub22266oqcxt.onion/10.18632/oncotarget.24603
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C5929403!5929403 !29731960
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suck abstract from ncbi


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pmid29731960
      Oncotarget 2018 ; 9 (28 ): 19481-19489
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  • Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin #MMPMID29731960
  • Woetmann A ; Alhede M ; Dabelsteen S ; Bjarnsholt T ; Rybtke M ; Nastasi C ; Krejsgaard T ; Andersen MH ; Bonefeld CM ; Geisler C ; Givskov M ; Odum N
  • Oncotarget 2018[Apr]; 9 (28 ): 19481-19489 PMID29731960 show ga
  • Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ, (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S. aureus. Thus, we provide novel evidence that IL-26 is an anti-microbial peptide produced by T cells in response to SE. Accordingly, we propose that IL-26 producing T cells take part in the innate immune response to SE producing S. aureus and thus play a novel role in the primary innate immune defense in addition to their classical role in adaptive immunity.
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