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2018 ; 9
(8
): 1365-1370
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Long-Term Outcome of Oxaliplatin and Capecitabine (XELOX) Concomitant with
Neoadjuvant Radiotherapy and Extended to the Resting Period in High Risk Locally
Advanced Rectal Cancer
#MMPMID29721045
Tang J
; Wu X
; Bai Y
; Gao Y
; Jiang W
; Kong L
; Lin J
; Wan D
; Pan Z
; Ding P
J Cancer
2018[]; 9
(8
): 1365-1370
PMID29721045
show ga
Purpose: This study aimed at investigating the long-term outcomes of oxaliplatin
and capecitabine (XELOX) administered concurrently with preoperative radiation
and extended to the resting period in patients with high-risk locally advanced
rectal cancer (LARC). Methods: From January 2010 to December 2013, 45 patients
were recruited. Study treatment consisted two cycles of XELOX regimen concomitant
with preoperative radiation and then followed by an additional cycle of XELOX
regimen between completion of neoadjuvant radiotherapy and surgery. Disease-free
survival (DFS) time and overall survival (OS) time were analyzed. Results: The
median follow-up was 51 months. Twelve (26.7%) patients developed local
recurrence or distant metastasis, including 10 (22.2%) patients developing
distant metastasis only, 1 (2.2%) patient local recurrence only, and 1 (2.2%)
patient both local recurrence and distant metastasis. The estimated 3-year DFS
and OS was 75.5% (95% CI, 63.0%-88.0%) and 88.6% (95% CI, 98.0%-79.2%),
respectively. Receiving adjuvant chemotherapy was a significant predictor for
DFS, with hazard ratio 0.24 (95% CI: 0.08-0.74). Conclusion: This intensified
strategy with oxaliplatin and capecitabine (XELOX) administered concomitantly
with neoadjuvant radiotherapy and then extended to the resting period in
high-risk LARC patients is efficient. The long-term outcome is promising. Further
study of this strategy is warranted.