Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1172/jci.insight.97470 http://scihub22266oqcxt.onion/10.1172/jci.insight.97470 C5928863!5928863!29618653     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight ä ; 3 (7): ä Nephropedia Template TP {{tp|p=29618653|t=ä. The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice |pdf=|usr=}}{{29618653}} gab.com Text The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=29618653 #FOAvip Secondary bacterial respiratory infections are commonly associated with both acute and chronic lung injury. Influenza complicated by bacterial pneumonia is an effective model to study host defense during pulmonary superinfection due to its clinical relevance. Multiprotein inflammasomes are responsible for IL-1? production in response to infection and drive tissue inflammation. In this study, we examined the role of the inflammasome during viral/bacterial superinfection. We demonstrate that ASC?/? mice are protected from bacterial superinfection and produce sufficient quantities of IL-1? through an apoptosis-associated speck-like protein containing CARD (ASC) inflammasome?independent mechanism. Despite the production of IL-1? by ASC?/? mice in response to bacterial superinfection, these mice display decreased lung inflammation. A neutrophil elastase inhibitor blocked ASC inflammasome?independent production of IL-1? and the IL-1 receptor antagonist, anakinra, confirmed that IL-1 remains crucial to the clearance of bacteria during superinfection. Delayed inhibition of NLRP3 during influenza infection by MCC950 decreases bacterial burden during superinfection and leads to decreased inflammatory cytokine production. Collectively, our results demonstrate that ASC augments the clearance of bacteria, but can also contribute to inflammation and mortality. ASC should be considered as a therapeutic target to decrease morbidity and mortality during bacterial superinfection. Twit Text FOAVip The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=29618653 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29618653 #FOAvip English Wikipedia <ref>{{Cite pmid|29618653}}</ref> The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice #MMPMID29618653 Robinson KM; Ramanan K; Clay ME; McHugh KJ; Pilewski MJ; Nickolich KL; Corey C; Shiva S; Wang J; Alcorn JF JCI Insight ä[]; 3 (7): ä PMID29618653show ga Secondary bacterial respiratory infections are commonly associated with both acute and chronic lung injury. Influenza complicated by bacterial pneumonia is an effective model to study host defense during pulmonary superinfection due to its clinical relevance. Multiprotein inflammasomes are responsible for IL-1? production in response to infection and drive tissue inflammation. In this study, we examined the role of the inflammasome during viral/bacterial superinfection. We demonstrate that ASC?/? mice are protected from bacterial superinfection and produce sufficient quantities of IL-1? through an apoptosis-associated speck-like protein containing CARD (ASC) inflammasome?independent mechanism. Despite the production of IL-1? by ASC?/? mice in response to bacterial superinfection, these mice display decreased lung inflammation. A neutrophil elastase inhibitor blocked ASC inflammasome?independent production of IL-1? and the IL-1 receptor antagonist, anakinra, confirmed that IL-1 remains crucial to the clearance of bacteria during superinfection. Delayed inhibition of NLRP3 during influenza infection by MCC950 decreases bacterial burden during superinfection and leads to decreased inflammatory cytokine production. Collectively, our results demonstrate that ASC augments the clearance of bacteria, but can also contribute to inflammation and mortality. ASC should be considered as a therapeutic target to decrease morbidity and mortality during bacterial superinfection. äThe inflammasome potentiates influenza/Staphylococcus aureus superinfe(epmc).pdf DeepDyve Pubget Overpricing