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10.3892/mmr.2018.8793 http://scihub22266oqcxt.onion/10.3892/mmr.2018.8793 C5928659!5928659 !29568935     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29568935 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2018 ; 17 (5 ): 7027-7036 Nephropedia Template TP {{tp|p=29568935 |t=2018. Integrated analysis of B?cell and T?cell receptors by high?throughput sequencing reveals conserved repertoires in IgA nephropathy |pdf=|usr=}}{{29568935 }} gab.com Text Integrated analysis of B cell and T cell receptors by high throughput sequencing reveals conserved repertoires in IgA nephropathy JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=29568935 #FOAvip Immunoglobulin A nephropathy (IgAN) is a type of glomerular disorder associated with immune dysregulation, and understanding B?/T?cell receptors (BCRs/TCRs) may be valuable for the development of specific immunotherapeutic interventions. In the present study, B and T cells were isolated from IgAN patients and healthy controls, and the composition of the BCR/TCR complementarity?determining region (CDR)3 was analyzed by multiplex polymerase chain reaction, high?throughput sequencing and bioinformatics. The present results revealed that the BCR/TCR CDR3 clones were expressed at very low frequencies, and the composition of clone types in patients with IgAN was skewed; the majority of clones were unique, and only 12 BCR and 228 TCR CDR3 clones were public ones, of which 16 were expressed at a significantly higher frequency in patients with IgAN (P<0.001). There were also certain conserved amino acid residues between unique clones or groups, and the residues GMDV, EQY and EQF were recurring only in the IgAN group. In addition, some VDJ gene recombinations indicated great variation between groups, including 4 high?frequency VDJ gene recombinations in the IgAN patients (P<0.001). Immune repertoires provide novel information, and conserved BCR/TCR CDR3 clones and VDJ gene recombinations with great variation may be potential therapeutic targets for IgAN patients. Twit Text FOAVip Integrated analysis of B cell and T cell receptors by high throughput sequencing reveals conserved repertoires in IgA nephropathy ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=29568935 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29568935 #FOAvip English Wikipedia <ref>{{Cite pmid|29568935 }}</ref> Integrated analysis of B?cell and T?cell receptors by high?throughput sequencing reveals conserved repertoires in IgA nephropathy #MMPMID29568935 Ou M ; Zheng F ; Zhang X ; Liu S ; Tang D ; Zhu P ; Qiu J ; Dai Y Mol Med Rep 2018[May]; 17 (5 ): 7027-7036 PMID29568935 show ga Immunoglobulin A nephropathy (IgAN) is a type of glomerular disorder associated with immune dysregulation, and understanding B?/T?cell receptors (BCRs/TCRs) may be valuable for the development of specific immunotherapeutic interventions. In the present study, B and T cells were isolated from IgAN patients and healthy controls, and the composition of the BCR/TCR complementarity?determining region (CDR)3 was analyzed by multiplex polymerase chain reaction, high?throughput sequencing and bioinformatics. The present results revealed that the BCR/TCR CDR3 clones were expressed at very low frequencies, and the composition of clone types in patients with IgAN was skewed; the majority of clones were unique, and only 12 BCR and 228 TCR CDR3 clones were public ones, of which 16 were expressed at a significantly higher frequency in patients with IgAN (P<0.001). There were also certain conserved amino acid residues between unique clones or groups, and the residues GMDV, EQY and EQF were recurring only in the IgAN group. In addition, some VDJ gene recombinations indicated great variation between groups, including 4 high?frequency VDJ gene recombinations in the IgAN patients (P<0.001). Immune repertoires provide novel information, and conserved BCR/TCR CDR3 clones and VDJ gene recombinations with great variation may be potential therapeutic targets for IgAN patients. |Adult [MESH] |Amino Acid Sequence [MESH] |B-Lymphocytes/metabolism/pathology [MESH] |Complementarity Determining Regions/*analysis/genetics [MESH] |Female [MESH] |Glomerulonephritis, IGA/genetics/*pathology [MESH] |High-Throughput Nucleotide Sequencing/methods [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Receptors, Antigen, B-Cell/*analysis/genetics [MESH] |Receptors, Antigen, T-Cell/*analysis/genetics [MESH] |T-Lymphocytes/metabolism/pathology [MESH]Integrated analysis of B?cell and T?cell receptors by high?throughput (epmc).pdf DeepDyve Pubget Overpricing