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10.3892/mmr.2018.8724 http://scihub22266oqcxt.onion/10.3892/mmr.2018.8724 C5928626!5928626 !29532876     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29532876 &cmd=llinks): Failed to open stream: HTTP request failed! 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Atorvastatin prevents glomerular extracellular matrix formation by interfering with the PKC signaling pathway |pdf=|usr=}}{{29532876 }} gab.com Text Atorvastatin prevents glomerular extracellular matrix formation by interfering with the PKC signaling pathway JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=29532876 #FOAvip Platelet-activating factor (PAF) promotes glomerular extracellular matrix (ECM) deposition, primarily through activation of the protein kinase C (PKC) pathway. The present study was designed to investigate whether atorvastatin, which mediates a protective effect against glomerular ECM deposition and diabetic neuropathy, may interfere with the PKC?transforming growth factor??1 (TGF??1) pathway in a model of human mesangial cells (HMCs) exposed to a high glucose (HG) and lysophosphatidylcholine (LPC) environment. HMCs were divided into three treatment groups: Control, high glucose and lysophosphatidylcholine (HG+LPC), and HG+LPC+atorvastatin. Cells were cultured for 24 h. The levels of the ECM?associated molecules collagen IV (Col IV) and fibronectin (Fn) in the supernatant were detected using an ELISA kit. PKC??1, TGF??1 and PAF?receptor gene expression was detected by reverse transcription?quantitative polymerase chain reaction. PKC??1 and TGF??1 protein expression was detected by western blotting, and the subcellular localization of PKC??1 was assessed using immunofluorescence. The results indicated that atorvastatin may reduce the secretion of ECM components (Fn and Col IV) in HMCs in a HG and LPC environment, by inhibiting the increase in PAF secretion and the activation of the PKC?TGF??1 signaling pathway. Twit Text FOAVip Atorvastatin prevents glomerular extracellular matrix formation by interfering with the PKC signaling pathway ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=29532876 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29532876 #FOAvip English Wikipedia <ref>{{Cite pmid|29532876 }}</ref> Atorvastatin prevents glomerular extracellular matrix formation by interfering with the PKC signaling pathway #MMPMID29532876 Xiao YH ; He XY ; Han Q ; Yang F ; Zhou SX Mol Med Rep 2018[May]; 17 (5 ): 6441-6448 PMID29532876 show ga Platelet-activating factor (PAF) promotes glomerular extracellular matrix (ECM) deposition, primarily through activation of the protein kinase C (PKC) pathway. The present study was designed to investigate whether atorvastatin, which mediates a protective effect against glomerular ECM deposition and diabetic neuropathy, may interfere with the PKC?transforming growth factor??1 (TGF??1) pathway in a model of human mesangial cells (HMCs) exposed to a high glucose (HG) and lysophosphatidylcholine (LPC) environment. HMCs were divided into three treatment groups: Control, high glucose and lysophosphatidylcholine (HG+LPC), and HG+LPC+atorvastatin. Cells were cultured for 24 h. The levels of the ECM?associated molecules collagen IV (Col IV) and fibronectin (Fn) in the supernatant were detected using an ELISA kit. PKC??1, TGF??1 and PAF?receptor gene expression was detected by reverse transcription?quantitative polymerase chain reaction. PKC??1 and TGF??1 protein expression was detected by western blotting, and the subcellular localization of PKC??1 was assessed using immunofluorescence. The results indicated that atorvastatin may reduce the secretion of ECM components (Fn and Col IV) in HMCs in a HG and LPC environment, by inhibiting the increase in PAF secretion and the activation of the PKC?TGF??1 signaling pathway. |Atorvastatin/*pharmacology [MESH] |Cell Line, Transformed [MESH] |Extracellular Matrix/*metabolism [MESH] |Glomerular Mesangium/*metabolism/pathology [MESH] |Humans [MESH] |Platelet Activating Factor/metabolism [MESH] |Protein Kinase C beta/*metabolism [MESH] |Signal Transduction/*drug effects [MESH]Atorvastatin prevents glomerular extracellular matrix formation by int(epmc).pdf DeepDyve Pubget Overpricing