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10.3233/BPL-160043 http://scihub22266oqcxt.onion/10.3233/BPL-160043 C5928571!5928571!29765854     free     free     free       Brain+Plast ä ; 2 (2): 153-69 Nephropedia Template TP {{tp|p=29765854|t=ä. Exercise in a Pill: The Latest on Exercise-Mimetics |pdf=|usr=}}{{29765854}} gab.com Text Exercise in a Pill: The Latest on Exercise-Mimetics JO: Brain Plast http://www.kidney.de/pget.php?&tw=1&pmid=29765854 #FOAvip There is increasing evidence that an active lifestyle benefits both body and brain. However, not everyone may be able to exercise due to disease, injury or aging-related frailty. Identification of cellular targets activated by physical activity may lead to the development of new compounds that can, to some extent, mimic systemic and central effects of exercise. This review will focus on factors relevant to energy metabolism in muscle, such as the 5? adenosine monophosphate-activated protein kinase (AMPK) - sirtuin (SIRT1) - Peroxisome proliferator-activated receptor ? coactivator-1? (PGC-1?) pathway, and the molecules affecting it. In particular, putative exercise-mimetics such as AICAR, metformin, and GW501516 will be discussed. Moreover, plant-derived polyphenols such as resveratrol and (-)epicatechin, with exercise-like effects on the body and brain will be evaluated. Twit Text FOAVip Exercise in a Pill: The Latest on Exercise-Mimetics ????Brain Plast http://www.kidney.de/pget.php?&tw=1&pmid=29765854 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29765854 #FOAvip English Wikipedia <ref>{{Cite pmid|29765854}}</ref> Exercise in a Pill: The Latest on Exercise-Mimetics #MMPMID29765854 Guerrieri D; Moon HY; van Praag H Brain Plast ä[]; 2 (2): 153-69 PMID29765854show ga There is increasing evidence that an active lifestyle benefits both body and brain. However, not everyone may be able to exercise due to disease, injury or aging-related frailty. Identification of cellular targets activated by physical activity may lead to the development of new compounds that can, to some extent, mimic systemic and central effects of exercise. This review will focus on factors relevant to energy metabolism in muscle, such as the 5? adenosine monophosphate-activated protein kinase (AMPK) - sirtuin (SIRT1) - Peroxisome proliferator-activated receptor ? coactivator-1? (PGC-1?) pathway, and the molecules affecting it. In particular, putative exercise-mimetics such as AICAR, metformin, and GW501516 will be discussed. Moreover, plant-derived polyphenols such as resveratrol and (-)epicatechin, with exercise-like effects on the body and brain will be evaluated. äExercise in a Pill: The Latest on Exercise-Mimetics (epmc).pdf DeepDyve Pubget Overpricing