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10.1038/s41598-018-24233-1 http://scihub22266oqcxt.onion/10.1038/s41598-018-24233-1 C5928146!5928146 !29712918     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29712918 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 6736 Nephropedia Template TP {{tp|p=29712918 |t=2018. High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages |pdf=|usr=}}{{29712918 }} gab.com Text High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29712918 #FOAvip Immune responses to parasitic pathogens are affected by the host physiological condition. High-density lipoprotein (HDL) and low-density lipoprotein (LDL) are transporters of lipids between the liver and peripheral tissues, and modulate pro-inflammatory immune responses. Pathogenic mycobacteria are parasitic intracellular bacteria that can survive within macrophages for a long period. Macrophage function is thus key for host defense against mycobacteria. These basic facts suggest possible effects of HDL and LDL on mycobacterial diseases, which have not been elucidated so far. In this study, we found that HDL and not LDL enhanced mycobacterial infections in human macrophages. Nevertheless, we observed that HDL remarkably suppressed production of tumor necrosis factor alpha (TNF-?) upon mycobacterial infections. TNF-? is a critical host-protective cytokine against mycobacterial diseases. We proved that toll-like receptor (TLR)-2 is responsible for TNF-? production by human macrophages infected with mycobacteria. Subsequent analysis showed that HDL downregulates TLR2 expression and suppresses its intracellular signaling pathways. This report demonstrates for the first time the substantial action of HDL in mycobacterial infections to human macrophages. Twit Text FOAVip High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29712918 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29712918 #FOAvip English Wikipedia <ref>{{Cite pmid|29712918 }}</ref> High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages #MMPMID29712918 Inoue M ; Niki M ; Ozeki Y ; Nagi S ; Chadeka EA ; Yamaguchi T ; Osada-Oka M ; Ono K ; Oda T ; Mwende F ; Kaneko Y ; Matsumoto M ; Kaneko S ; Ichinose Y ; Njenga SM ; Hamano S ; Matsumoto S Sci Rep 2018[Apr]; 8 (1 ): 6736 PMID29712918 show ga Immune responses to parasitic pathogens are affected by the host physiological condition. High-density lipoprotein (HDL) and low-density lipoprotein (LDL) are transporters of lipids between the liver and peripheral tissues, and modulate pro-inflammatory immune responses. Pathogenic mycobacteria are parasitic intracellular bacteria that can survive within macrophages for a long period. Macrophage function is thus key for host defense against mycobacteria. These basic facts suggest possible effects of HDL and LDL on mycobacterial diseases, which have not been elucidated so far. In this study, we found that HDL and not LDL enhanced mycobacterial infections in human macrophages. Nevertheless, we observed that HDL remarkably suppressed production of tumor necrosis factor alpha (TNF-?) upon mycobacterial infections. TNF-? is a critical host-protective cytokine against mycobacterial diseases. We proved that toll-like receptor (TLR)-2 is responsible for TNF-? production by human macrophages infected with mycobacteria. Subsequent analysis showed that HDL downregulates TLR2 expression and suppresses its intracellular signaling pathways. This report demonstrates for the first time the substantial action of HDL in mycobacterial infections to human macrophages. |Cytokines/genetics [MESH] |Gene Expression Regulation/genetics [MESH] |Humans [MESH] |Lipoproteins, HDL/*genetics [MESH] |Lipoproteins, LDL/genetics [MESH] |Macrophages/metabolism/microbiology/pathology [MESH] |Mycobacterium Infections/*genetics/microbiology [MESH] |Mycobacterium tuberculosis/genetics/pathogenicity [MESH] |Signal Transduction/genetics [MESH] |Toll-Like Receptor 2/*genetics [MESH]High-density lipoprotein suppresses tumor necrosis factor alpha produc(epmc).pdf DeepDyve Pubget Overpricing