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10.1038/s41467-018-04130-x http://scihub22266oqcxt.onion/10.1038/s41467-018-04130-x C5928121!5928121!29712907     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29712907|t=2018. Theoretical principles of transcription factor traffic on folded chromatin |pdf=|usr=}}{{29712907}} gab.com Text Theoretical principles of transcription factor traffic on folded chromatin JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29712907 #FOAvip All organisms regulate transcription of their genes. To understand this process, a complete understanding of how transcription factors find their targets in cellular nuclei is essential. The DNA sequence and other variables are known to influence this binding, but the distribution of transcription factor binding patterns remains mostly unexplained in metazoan genomes. Here, we investigate the role of chromosome conformation in the trajectories of transcription factors. Using molecular dynamics simulations, we uncover the principles of their diffusion on chromatin. Chromosome contacts play a conflicting role: at low density they enhance transcription factor traffic, but at high density they lower it by volume exclusion. Consistently, we observe that in human cells, highly occupied targets, where protein binding is promiscuous, are found at sites engaged in chromosome loops within uncompacted chromatin. In summary, we provide a framework for understanding the search trajectories of transcription factors, highlighting the key contribution of genome conformation. Twit Text FOAVip Theoretical principles of transcription factor traffic on folded chromatin ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29712907 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29712907 #FOAvip English Wikipedia <ref>{{Cite pmid|29712907}}</ref> Theoretical principles of transcription factor traffic on folded chromatin #MMPMID29712907 Cortini R; Filion GJ Nat Commun 2018[]; 9 (ä): ä PMID29712907show ga All organisms regulate transcription of their genes. To understand this process, a complete understanding of how transcription factors find their targets in cellular nuclei is essential. The DNA sequence and other variables are known to influence this binding, but the distribution of transcription factor binding patterns remains mostly unexplained in metazoan genomes. Here, we investigate the role of chromosome conformation in the trajectories of transcription factors. Using molecular dynamics simulations, we uncover the principles of their diffusion on chromatin. Chromosome contacts play a conflicting role: at low density they enhance transcription factor traffic, but at high density they lower it by volume exclusion. Consistently, we observe that in human cells, highly occupied targets, where protein binding is promiscuous, are found at sites engaged in chromosome loops within uncompacted chromatin. In summary, we provide a framework for understanding the search trajectories of transcription factors, highlighting the key contribution of genome conformation. äTheoretical principles of transcription factor traffic on folded chrom(epmc).pdf DeepDyve Pubget Overpricing