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10.1038/s41598-018-24935-6 http://scihub22266oqcxt.onion/10.1038/s41598-018-24935-6 C5928089!5928089 !29712938     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29712938 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 6737 Nephropedia Template TP {{tp|p=29712938 |t=2018. Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network |pdf=|usr=}}{{29712938 }} gab.com Text Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29712938 #FOAvip Whole-transcriptome analysis and western blotting of sauchinone-treated HepG2 cells demonstrated that sauchinone regulated genes relevant to cholesterol metabolism and synthesis. In particular, it was found that the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) was downregulated, and the expression of low density lipoprotein receptor (LDLR) was upregulated in sauchinone-treated HepG2 cells. Consequently, LDL-cholesterol (LDL-C) uptake was increased. As a transcriptional regulator of PCSK9 expression, sterol regulatory elements binding protein-2 (SREBP-2) was proposed by transcriptome analysis and western blotting. Oral administration of sauchinone increased hepatic LDLR through PCSK9 inhibition in obese mice and showed the reduced serum LDL-C levels and downstream targets of SREBP-2. Thus, it is evident that sauchinone reduces hepatic steatosis by downregulating the expression of hepatic PCSK9 via SREBP-2. Twit Text FOAVip Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29712938 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29712938 #FOAvip English Wikipedia <ref>{{Cite pmid|29712938 }}</ref> Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network #MMPMID29712938 Chae HS ; You BH ; Kim DY ; Lee H ; Ko HW ; Ko HJ ; Choi YH ; Choi SS ; Chin YW Sci Rep 2018[Apr]; 8 (1 ): 6737 PMID29712938 show ga Whole-transcriptome analysis and western blotting of sauchinone-treated HepG2 cells demonstrated that sauchinone regulated genes relevant to cholesterol metabolism and synthesis. In particular, it was found that the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) was downregulated, and the expression of low density lipoprotein receptor (LDLR) was upregulated in sauchinone-treated HepG2 cells. Consequently, LDL-cholesterol (LDL-C) uptake was increased. As a transcriptional regulator of PCSK9 expression, sterol regulatory elements binding protein-2 (SREBP-2) was proposed by transcriptome analysis and western blotting. Oral administration of sauchinone increased hepatic LDLR through PCSK9 inhibition in obese mice and showed the reduced serum LDL-C levels and downstream targets of SREBP-2. Thus, it is evident that sauchinone reduces hepatic steatosis by downregulating the expression of hepatic PCSK9 via SREBP-2. |Animals [MESH] |Benzopyrans/*administration & dosage [MESH] |Cholesterol, LDL/genetics [MESH] |Cholesterol/genetics/metabolism [MESH] |Dioxoles/*administration & dosage [MESH] |Disease Models, Animal [MESH] |Fatty Liver/blood/*drug therapy/genetics/pathology [MESH] |Gene Expression Regulation/drug effects [MESH] |Gene Regulatory Networks/drug effects [MESH] |Hep G2 Cells [MESH] |Homeostasis/drug effects [MESH] |Humans [MESH] |Lipid Metabolism/drug effects [MESH] |Liver/drug effects/metabolism/pathology [MESH] |Mice [MESH] |Proprotein Convertase 9/*genetics [MESH] |Receptors, LDL/genetics [MESH] |Sterol Regulatory Element Binding Protein 2/*genetics [MESH]Sauchinone controls hepatic cholesterol homeostasis by the negative re(epmc).pdf DeepDyve Pubget Overpricing