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10.1016/j.celrep.2016.12.037 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.12.037 C5926788!5926788 !28076790     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28076790 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Anti-Warburg Effect Elicited by the cAMP-PGC1? Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes |pdf=|usr=}}{{28076790 }} gab.com Text The Anti-Warburg Effect Elicited by the cAMP-PGC1 Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28076790 #FOAvip Glioblastoma multiforme (GBM) is among the most aggressive of human cancers. Although differentiation therapy has been proposed as a potential approach to treat GBM, the mechanisms of induced differentiation remain poorly defined. Here, we established an induced differentiation model of GBM using cAMP activators that specifically directed GBM differentiation into astroglia. Transcriptomic and proteomic analyses revealed that oxidative phosphorylation and mitochondrial biogenesis are involved in induced differentiation of GBM. Dibutyryl cyclic AMP (dbcAMP) reverses the Warburg effect, as evidenced by increased oxygen consumption and reduced lactate production. Mitochondrial biogenesis induced by activation of the CREB-PGC1? pathway triggers metabolic shift and differentiation. Blocking mitochondrial biogenesis using mdivi1 or by silencing PGC1? abrogates differentiation; conversely, overexpression of PGC1? elicits differentiation. In GBM xenograft models and patient-derived GBM samples, cAMP activators also induce tumor growth inhibition and differentiation. Our data show that mitochondrial biogenesis and metabolic switch to oxidative phosphorylation drive the differentiation of tumor cells. Twit Text FOAVip The Anti-Warburg Effect Elicited by the cAMP-PGC1 Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28076790 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28076790 #FOAvip English Wikipedia <ref>{{Cite pmid|28076790 }}</ref> The Anti-Warburg Effect Elicited by the cAMP-PGC1? Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes #MMPMID28076790 Xing F ; Luan Y ; Cai J ; Wu S ; Mai J ; Gu J ; Zhang H ; Li K ; Lin Y ; Xiao X ; Liang J ; Li Y ; Chen W ; Tan Y ; Sheng L ; Lu B ; Lu W ; Gao M ; Qiu P ; Su X ; Yin W ; Hu J ; Chen Z ; Sai K ; Wang J ; Chen F ; Chen Y ; Zhu S ; Liu D ; Cheng S ; Xie Z ; Zhu W ; Yan G Cell Rep 2017[Jan]; 18 (2 ): 468-481 PMID28076790 show ga Glioblastoma multiforme (GBM) is among the most aggressive of human cancers. Although differentiation therapy has been proposed as a potential approach to treat GBM, the mechanisms of induced differentiation remain poorly defined. Here, we established an induced differentiation model of GBM using cAMP activators that specifically directed GBM differentiation into astroglia. Transcriptomic and proteomic analyses revealed that oxidative phosphorylation and mitochondrial biogenesis are involved in induced differentiation of GBM. Dibutyryl cyclic AMP (dbcAMP) reverses the Warburg effect, as evidenced by increased oxygen consumption and reduced lactate production. Mitochondrial biogenesis induced by activation of the CREB-PGC1? pathway triggers metabolic shift and differentiation. Blocking mitochondrial biogenesis using mdivi1 or by silencing PGC1? abrogates differentiation; conversely, overexpression of PGC1? elicits differentiation. In GBM xenograft models and patient-derived GBM samples, cAMP activators also induce tumor growth inhibition and differentiation. Our data show that mitochondrial biogenesis and metabolic switch to oxidative phosphorylation drive the differentiation of tumor cells. |*Cell Differentiation/drug effects [MESH] |*Glycolysis/drug effects [MESH] |8-Bromo Cyclic Adenosine Monophosphate/analogs & derivatives/pharmacology [MESH] |Astrocytes/metabolism/*pathology/ultrastructure [MESH] |Brain Neoplasms/genetics/metabolism/*pathology/ultrastructure [MESH] |Cell Death/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |Cyclic AMP Response Element-Binding Protein/metabolism [MESH] |Cyclic AMP/*metabolism [MESH] |Gene Expression Profiling [MESH] |Glial Fibrillary Acidic Protein/metabolism [MESH] |Glioblastoma/genetics/*metabolism/*pathology/ultrastructure [MESH] |Humans [MESH] |Organelle Biogenesis [MESH] |Oxidative Phosphorylation/drug effects [MESH] |Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*metabolism [MESH] |Proteomics [MESH] |Signal Transduction [MESH]The Anti-Warburg Effect Elicited by the cAMP-PGC1? 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