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10.1111/j.1349-7006.2001.tb01111.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.2001.tb01111.x C5926720!5926720 !11346464     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\11346464 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Jpn+J+Cancer+Res 2001 ; 92 (4 ): 417-22 Nephropedia Template TP {{tp|p=11346464 |t=2001. Down-regulation in multiple human cancers of a novel gene, DMHC, from 17q25 1 that encodes an integral membrane protein |pdf=|usr=}}{{11346464 }} gab.com Text Down-regulation in multiple human cancers of a novel gene, DMHC, from 17q25 1 that encodes an integral membrane protein JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=11346464 #FOAvip Frequent observations of allelic loss in chromosomal band 17q25.1 in a variety of human cancers have suggested that one or more tumor suppressor genes are present in that region. Moreover, a genetic locus for hereditary focal non-epidermolytic palmoplantar keratoderma, a condition associated with cancer of the esophagus (TOC; Tylosis with Oesophageal Cancer), lies in the same region. We screened cell lines derived from a variety of human cancers by reverse transcription-polymerase chain reaction (RT-PCR) to detect alterations in expression of genes within the region in question, by examining expressed sequence tags located there. These experiments identified an 1834-bp full-length cDNA encoding a novel, 441-amino acid integral membrane protein with seven putative transmembrane domains. This gene showed loss or extreme decrease of expression in 6 of 10 uterine cancer-cell lines, 2 of 11 hepatic cell carcinoma-cell lines, 2 of 7 lung cancer-cell lines, 1 of 6 gastric cancer-cell lines, and 1 of 10 breast cancer-cell lines. (We named it DMHC ("down-regulated in multiple human cancers").) Our results suggest that loss of expression of DMHC at 17q25.1 may play an important role in development of variety of human cancers. Twit Text FOAVip Down-regulation in multiple human cancers of a novel gene, DMHC, from 17q25 1 that encodes an integral membrane protein ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=11346464 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11346464 #FOAvip English Wikipedia <ref>{{Cite pmid|11346464 }}</ref> Down-regulation in multiple human cancers of a novel gene, DMHC, from 17q25 1 that encodes an integral membrane protein #MMPMID11346464 Mikami I ; Harada H ; Nagai H ; Tsuneizumi M ; Nobe Y ; Koizumi K ; Sugano S ; Tanaka S ; Emi M Jpn J Cancer Res 2001[Apr]; 92 (4 ): 417-22 PMID11346464 show ga Frequent observations of allelic loss in chromosomal band 17q25.1 in a variety of human cancers have suggested that one or more tumor suppressor genes are present in that region. Moreover, a genetic locus for hereditary focal non-epidermolytic palmoplantar keratoderma, a condition associated with cancer of the esophagus (TOC; Tylosis with Oesophageal Cancer), lies in the same region. We screened cell lines derived from a variety of human cancers by reverse transcription-polymerase chain reaction (RT-PCR) to detect alterations in expression of genes within the region in question, by examining expressed sequence tags located there. These experiments identified an 1834-bp full-length cDNA encoding a novel, 441-amino acid integral membrane protein with seven putative transmembrane domains. This gene showed loss or extreme decrease of expression in 6 of 10 uterine cancer-cell lines, 2 of 11 hepatic cell carcinoma-cell lines, 2 of 7 lung cancer-cell lines, 1 of 6 gastric cancer-cell lines, and 1 of 10 breast cancer-cell lines. (We named it DMHC ("down-regulated in multiple human cancers").) Our results suggest that loss of expression of DMHC at 17q25.1 may play an important role in development of variety of human cancers. |Amino Acid Sequence [MESH] |Base Sequence [MESH] |Chromosomes, Human, Pair 17/*genetics [MESH] |Cloning, Molecular [MESH] |DNA, Complementary/genetics [MESH] |DNA, Neoplasm/genetics [MESH] |Down-Regulation [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Membrane Proteins/biosynthesis/*genetics [MESH] |Molecular Sequence Data [MESH] |Neoplasms/*genetics/metabolism [MESH] |Protein Structure, Secondary [MESH] |Protein Structure, Tertiary [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH]Down-regulation in multiple human cancers of a novel gene, DMHC, from (epmc).pdf DeepDyve Pubget Overpricing