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10.1111/j.1349-7006.2001.tb01066.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.2001.tb01066.x C5926615!5926615 !11676862     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\11676862 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Jpn+J+Cancer+Res 2001 ; 92 (10 ): 1110-5 Nephropedia Template TP {{tp|p=11676862 |t=2001. Antitumor effect of the idiotypic cascade induced by an antibody encapsulated in poly(d,l-lactide-co-glycolide) microspheres |pdf=|usr=}}{{11676862 }} gab.com Text Antitumor effect of the idiotypic cascade induced by an antibody encapsulated in poly(d,l-lactide-co-glycolide) microspheres JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=11676862 #FOAvip A major difficulty encountered during development of antibody vaccines is their weak immunogenicity. In this study, a monoclonal antibody CS20.5 to human breast cancer antigen CA15.3 was coencapsulated in poly(d,l-lactide-co-glycolide) microspheres with monophosphoryl lipid A. The antitumor effect of this formulation was investigated in a murine model. The induced Ab2 biologically mimics antigen as it competed with CA15.3 for the same idiotope on Ab1. Ab3 induction was also observed. After five sequential administrations of encapsulated antibody, mice showed statistically significant tumor regression. These results indicate that this formulation may serve as a potential treatment for breast cancer. Twit Text FOAVip Antitumor effect of the idiotypic cascade induced by an antibody encapsulated in poly(d,l-lactide-co-glycolide) microspheres ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=11676862 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11676862 #FOAvip English Wikipedia <ref>{{Cite pmid|11676862 }}</ref> Antitumor effect of the idiotypic cascade induced by an antibody encapsulated in poly(d,l-lactide-co-glycolide) microspheres #MMPMID11676862 Ma J ; Luo D ; Qi W ; Cao L Jpn J Cancer Res 2001[Oct]; 92 (10 ): 1110-5 PMID11676862 show ga A major difficulty encountered during development of antibody vaccines is their weak immunogenicity. In this study, a monoclonal antibody CS20.5 to human breast cancer antigen CA15.3 was coencapsulated in poly(d,l-lactide-co-glycolide) microspheres with monophosphoryl lipid A. The antitumor effect of this formulation was investigated in a murine model. The induced Ab2 biologically mimics antigen as it competed with CA15.3 for the same idiotope on Ab1. Ab3 induction was also observed. After five sequential administrations of encapsulated antibody, mice showed statistically significant tumor regression. These results indicate that this formulation may serve as a potential treatment for breast cancer. |*Lactic Acid [MESH] |*Polyglycolic Acid [MESH] |*Polymers [MESH] |Animals [MESH] |Antibodies, Anti-Idiotypic/biosynthesis/*immunology [MESH] |Antibodies, Monoclonal/administration & dosage/immunology/metabolism [MESH] |Antibodies, Neoplasm/administration & dosage/biosynthesis/*immunology [MESH] |Antibody Specificity [MESH] |Antineoplastic Agents/immunology [MESH] |Breast Neoplasms/*immunology/*therapy [MESH] |Drug Carriers [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Female [MESH] |Humans [MESH] |Immunoglobulin G/biosynthesis/immunology [MESH] |Immunoglobulin Idiotypes/administration & dosage/*immunology/metabolism [MESH] |Immunoglobulin Isotypes/biosynthesis/immunology [MESH] |Immunoglobulin M/biosynthesis/immunology [MESH] |Immunotherapy/*methods [MESH] |Mice [MESH] |Microspheres [MESH] |Neoplasm Transplantation [MESH] |Polylactic Acid-Polyglycolic Acid Copolymer [MESH]Antitumor effect of the idiotypic cascade induced by an antibody encap(epmc).pdf DeepDyve Pubget Overpricing