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10.1111/j.1349-7006.2001.tb01042.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.2001.tb01042.x C5926584!5926584!11173539     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Jpn+J+Cancer+Res 2001 ; 92 (1): 16-22 Nephropedia Template TP {{tp|p=11173539|t=2001. Alterations of the Transforming Growth Factor?(? Signaling Pathway in Hepatocellular Carcinomas Induced Endogenously and Exogenously in Rats |pdf=|usr=}}{{11173539}} gab.com Text Alterations of the Transforming Growth Factor ( Signaling Pathway in Hepatocellular Carcinomas Induced Endogenously and Exogenously in Rats JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=11173539 #FOAvip To elucidate involvement of the transforming growth factor?? (TGF??) signaling pathway in endogenous and exogenous liver carcinogenesis, we investigated mutations of TGF?? receptor type II (TGF??RII), Smad2 and Smad4 genes, and expression of TGF??RII in hepatocellular carcinomas (HCCs) induced by a choline?deficient L?amino acid?defined (CDAA) diet and by N?nitrosodiethyl?amine (DEN). Male Fischer 344 rats received a CDAA diet continuously and HCCs were sampled after 75 weeks. Administration of DEN was followed by partial hepatectomy (PH), with colchicine to induce cell cycle disturbance and a selection pressure regimen, HCCs being obtained after 42 weeks. Total RNAs were extracted from individual HCCs and mutations in TGF?PRH, Smad2 and Smad4 were investigated by reverse transcription (RT)?polymerase chain reaction (PCR)?restric?tion?single?strand conformation polymorphism (SSCP) analysis followed by sequencing analysis. Mutations of Smad2 were detected in 2 out of 12 HCCs (16.7%) induced by the CDAA diet, a GGT?to?GGC transition (Gly to Gly) at codon 30 and a TCT?to?GCT (Ser to Ala) transversion at codon 118, without any TGF??RII or Smad4 alterations. No mutations of TGF??RII, Smad2 and Smad4 were encountered in eleven HCCs induced by the exogenous carcinogen. Semi?quantitative RT?PCR revealed reduced expression of TGF??RII in 2 HCCs (16.7%) without Smad2 mutations out of 12 HCCs induced by the CDAA diet and none of 11 induced by DEN. These results suggest that the TGF?p signaling pathway may be disturbed in endogenous liver carcinogenesis in rats. Twit Text FOAVip Alterations of the Transforming Growth Factor ( Signaling Pathway in Hepatocellular Carcinomas Induced Endogenously and Exogenously in Rats ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=11173539 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11173539 #FOAvip English Wikipedia <ref>{{Cite pmid|11173539}}</ref> Alterations of the Transforming Growth Factor?(? Signaling Pathway in Hepatocellular Carcinomas Induced Endogenously and Exogenously in Rats #MMPMID11173539 Sasaki Y; Tsujiuchi T; Murata N; Tsutsumi M; Konishi Y Jpn J Cancer Res 2001[Jan]; 92 (1): 16-22 PMID11173539show ga To elucidate involvement of the transforming growth factor?? (TGF??) signaling pathway in endogenous and exogenous liver carcinogenesis, we investigated mutations of TGF?? receptor type II (TGF??RII), Smad2 and Smad4 genes, and expression of TGF??RII in hepatocellular carcinomas (HCCs) induced by a choline?deficient L?amino acid?defined (CDAA) diet and by N?nitrosodiethyl?amine (DEN). Male Fischer 344 rats received a CDAA diet continuously and HCCs were sampled after 75 weeks. Administration of DEN was followed by partial hepatectomy (PH), with colchicine to induce cell cycle disturbance and a selection pressure regimen, HCCs being obtained after 42 weeks. Total RNAs were extracted from individual HCCs and mutations in TGF?PRH, Smad2 and Smad4 were investigated by reverse transcription (RT)?polymerase chain reaction (PCR)?restric?tion?single?strand conformation polymorphism (SSCP) analysis followed by sequencing analysis. Mutations of Smad2 were detected in 2 out of 12 HCCs (16.7%) induced by the CDAA diet, a GGT?to?GGC transition (Gly to Gly) at codon 30 and a TCT?to?GCT (Ser to Ala) transversion at codon 118, without any TGF??RII or Smad4 alterations. No mutations of TGF??RII, Smad2 and Smad4 were encountered in eleven HCCs induced by the exogenous carcinogen. Semi?quantitative RT?PCR revealed reduced expression of TGF??RII in 2 HCCs (16.7%) without Smad2 mutations out of 12 HCCs induced by the CDAA diet and none of 11 induced by DEN. These results suggest that the TGF?p signaling pathway may be disturbed in endogenous liver carcinogenesis in rats. äAlterations of the Transforming Growth Factor?(? Signaling Pathway in (epmc).pdf DeepDyve Pubget Overpricing