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10.1111/j.1349-7006.2000.tb00924.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.2000.tb00924.x C5926298!5926298!11123436     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Jpn+J+Cancer+Res 2000 ; 91 (12): 1345-9 Nephropedia Template TP {{tp|p=11123436|t=2000. Atypical Osteosarcomas in Werner Syndrome (Adult Progeria) |pdf=|usr=}}{{11123436}} gab.com Text Atypical Osteosarcomas in Werner Syndrome (Adult Progeria) JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=11123436 #FOAvip Werner syndrome (WS), adult progeria, is more common in Japan than elsewhere. It predisposes to osteosarcoma (OS) and five other rare tumors. To determine if and how OS is atypical in this genetic disorder, we studied the characteristics of ten Japanese cases with respect to clinical features, pathology, and radiographs, and compared them with a hospital series of 36 skeletal OS with the same atypical age?range, 35?57 years. The anatomic sites were also atypical: seven ankle/foot, two radius and one patella compared with only one at the ankle in the hospital series. The osteoblastic cell?type was about equally frequent in both series, but, among others than the three major subtypes, there was only one in WS as compared with 14 (39%) in the hospital series. The types of mutations were sought in five WS cases with OS. One showed no mutation at any of the ten known loci for Japanese, two were of type 4/4 and two of type 6/6. The mutations 4 and 6 have been found in 66% of alleles of WS cases in Japan. The increased frequency and unusual age and site distributions of OS in WS may be due to increased susceptibility, related to later?life leg ulcers, and weight?bearing on spindly ankles weakened by severe loss of lower limb subcutaneous tissue. Twit Text FOAVip Atypical Osteosarcomas in Werner Syndrome (Adult Progeria) ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=11123436 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11123436 #FOAvip English Wikipedia <ref>{{Cite pmid|11123436}}</ref> Atypical Osteosarcomas in Werner Syndrome (Adult Progeria) #MMPMID11123436 Ishikawa Y; Miller RW; Machinami R; Sugano H; Goto M Jpn J Cancer Res 2000[Dec]; 91 (12): 1345-9 PMID11123436show ga Werner syndrome (WS), adult progeria, is more common in Japan than elsewhere. It predisposes to osteosarcoma (OS) and five other rare tumors. To determine if and how OS is atypical in this genetic disorder, we studied the characteristics of ten Japanese cases with respect to clinical features, pathology, and radiographs, and compared them with a hospital series of 36 skeletal OS with the same atypical age?range, 35?57 years. The anatomic sites were also atypical: seven ankle/foot, two radius and one patella compared with only one at the ankle in the hospital series. The osteoblastic cell?type was about equally frequent in both series, but, among others than the three major subtypes, there was only one in WS as compared with 14 (39%) in the hospital series. The types of mutations were sought in five WS cases with OS. One showed no mutation at any of the ten known loci for Japanese, two were of type 4/4 and two of type 6/6. The mutations 4 and 6 have been found in 66% of alleles of WS cases in Japan. The increased frequency and unusual age and site distributions of OS in WS may be due to increased susceptibility, related to later?life leg ulcers, and weight?bearing on spindly ankles weakened by severe loss of lower limb subcutaneous tissue. äAtypical Osteosarcomas in Werner Syndrome (Adult Progeria) (epmc).pdf DeepDyve Pubget Overpricing