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1999 ; 90
(8
): 801-4
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gab.com Text
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English Wikipedia
Natural killer T cell ligand alpha-galactosylceramide inhibited lymph node
metastasis of highly metastatic melanoma cells
#MMPMID10543249
Nakui M
; Iwakabe K
; Ohta A
; Sekimoto M
; Sato M
; Makuuchi H
; Kawano T
; Taniguchi M
; Nishimura T
Jpn J Cancer Res
1999[Aug]; 90
(8
): 801-4
PMID10543249
show ga
The role of natural killer T (NKT) cells in the prevention of multiple tumor
metastasis was examined. The i.v. inoculation of a highly metastatic subline of
B16-BL6 (B16-BL6-HM) melanoma cells resulted in the formation of metastatic
nodules in lymph nodes in addition to lung, intrapleural cavity, and ovary.
However, treatment of the mice with the NKT cell ligand alpha-galactosylceramide
(alpha-GalCer) three times from 1 day after B16-BL6-HM melanoma inoculation
caused a significant inhibition of multiple metastasis. Lymph node metastasis of
B16-BL6-HM was almost completely blocked by alpha-GalCer treatment. This
antimetastatic effect of alpha-GalCer was abolished in NKT cell-deficient mice.
These results suggest that alpha-GalCer-activated NKT cells played a critical
role in the prevention of lymph node metastasis of melanoma cells.