Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=10076568
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\10076568
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Jpn+J+Cancer+Res
1999 ; 90
(1
): 75-80
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Peroxisome proliferator-activated receptor gamma induces growth arrest and
differentiation markers of human colon cancer cells
#MMPMID10076568
Kitamura S
; Miyazaki Y
; Shinomura Y
; Kondo S
; Kanayama S
; Matsuzawa Y
Jpn J Cancer Res
1999[Jan]; 90
(1
): 75-80
PMID10076568
show ga
Peroxisome proliferator-activated receptor gamma (PPAR gamma), one of the nuclear
receptors expressed in adipose tissue, plays an important role in adipocyte
differentiation. In this study, we investigated the expression of PPAR gamma and
its role in cellular growth and differentiation in six colon cancer cell lines:
HT-29, CaCo-2, SW-480, DLD-1, LoVo, and T-84. All six expressed PPAR gamma mRNA
and protein, shown respectively on northern and western blot analyses. Luciferase
assay in HT-29 cells, which strongly express PPAR gamma, showed that
troglitazone, a selective ligand for PPAR gamma, transactivated the transcription
of a peroxisome proliferator response element (PPRE)-driven promoter.
Furthermore, troglitazone caused a marked decrease in [3H]thymidine incorporation
and G1 cell-cycle arrest determined by flow cytometry. Finally, troglitazone
induced expression of mRNAs for villin and intestinal alkaline phosphatase,
markers for enterocyte differentiation. In conclusion, human colon cancer cells
express PPAR gamma, the ligands of which inhibit cell growth and induce
differentiation markers.
|*Thiazolidinediones
[MESH]
|*Transcription, Genetic/*drug effects
[MESH]
|Calcium-Binding Proteins/genetics
[MESH]
|Carrier Proteins/genetics
[MESH]
|Cell Differentiation
[MESH]
|Cell Division
[MESH]
|Chromans/*pharmacology
[MESH]
|Colonic Neoplasms
[MESH]
|Genes, Reporter
[MESH]
|Humans
[MESH]
|Luciferases/genetics
[MESH]
|Microfilament Proteins/genetics
[MESH]
|Nuclear Proteins/metabolism
[MESH]
|Promoter Regions, Genetic/drug effects
[MESH]
|RNA, Messenger/genetics
[MESH]
|Receptors, Cytoplasmic and Nuclear/*genetics/*physiology
[MESH]