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10.3389/fimmu.2018.00842 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00842 C5925960!5925960 !29740445     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 282.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 282.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 282.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 282.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29740445 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Immunol 2018 ; 9 (ä): 842 Nephropedia Template TP {{tp|p=29740445 |t=2018. Loss of Perp in T Cells Promotes Resistance to Apoptosis of T Helper 17 Cells and Exacerbates the Development of Experimental Autoimmune Encephalomyelitis in Mice |pdf=|usr=}}{{29740445 }} gab.com Text Loss of Perp in T Cells Promotes Resistance to Apoptosis of T Helper 17 Cells and Exacerbates the Development of Experimental Autoimmune Encephalomyelitis in Mice JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29740445 #FOAvip T helper 17 (Th17) cells are crucial for the pathogenesis of multiple sclerosis (MS) in humans and experimental autoimmune encephalomyelitis (EAE) in animals. High frequency of Th17?cells and low sensitivity to activation-induced cell death (AICD) are detected in MS patients. However, the mechanisms underlying apoptosis resistance of T cells remain unclear. Perp is an apoptosis-associated target of p53 and implicated in the development of cancers. Here, we show that loss of Perp in T cells does not affect Th1, Th17, or Treg cell differentiation, but does significantly increase the resistance of Perp(-/-) Th17?cells to AICD and anti-Fas in Lck-Cre?×?Perp(fl/fl) mice by inhibiting the caspase-dependent apoptotic pathway. Moreover, Lck-Cre?×?Perp(fl/fl) mice exhibited earlier onset of EAE and severe spinal cord inflammation and demyelination, accompanied by increased levels of pro-inflammatory cytokines and enlarged population of Th17?cells. Therefore, Perp deletion promoted Th17 responses and exacerbated the development and severity of EAE. Twit Text FOAVip Loss of Perp in T Cells Promotes Resistance to Apoptosis of T Helper 17 Cells and Exacerbates the Development of Experimental Autoimmune Encephalomyelitis in Mice ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29740445 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29740445 #FOAvip English Wikipedia <ref>{{Cite pmid|29740445 }}</ref> Loss of Perp in T Cells Promotes Resistance to Apoptosis of T Helper 17 Cells and Exacerbates the Development of Experimental Autoimmune Encephalomyelitis in Mice #MMPMID29740445 Zhou Y ; Leng X ; He Y ; Li Y ; Liu Y ; Liu Y ; Zou Q ; Shi G ; Wang Y Front Immunol 2018[]; 9 (ä): 842 PMID29740445 show ga T helper 17 (Th17) cells are crucial for the pathogenesis of multiple sclerosis (MS) in humans and experimental autoimmune encephalomyelitis (EAE) in animals. High frequency of Th17?cells and low sensitivity to activation-induced cell death (AICD) are detected in MS patients. However, the mechanisms underlying apoptosis resistance of T cells remain unclear. Perp is an apoptosis-associated target of p53 and implicated in the development of cancers. Here, we show that loss of Perp in T cells does not affect Th1, Th17, or Treg cell differentiation, but does significantly increase the resistance of Perp(-/-) Th17?cells to AICD and anti-Fas in Lck-Cre?×?Perp(fl/fl) mice by inhibiting the caspase-dependent apoptotic pathway. Moreover, Lck-Cre?×?Perp(fl/fl) mice exhibited earlier onset of EAE and severe spinal cord inflammation and demyelination, accompanied by increased levels of pro-inflammatory cytokines and enlarged population of Th17?cells. Therefore, Perp deletion promoted Th17 responses and exacerbated the development and severity of EAE. |*Apoptosis [MESH] |Animals [MESH] |Caspases/metabolism [MESH] |Cell Differentiation [MESH] |Disease Progression [MESH] |Encephalomyelitis, Autoimmune, Experimental/*immunology [MESH] |Female [MESH] |Gene Deletion [MESH] |Lymphocyte Activation [MESH] |Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics [MESH] |Male [MESH] |Membrane Proteins/*genetics/immunology [MESH] |Mice [MESH] |Spinal Cord/immunology/pathology [MESH] |T-Lymphocytes, Regulatory/immunology [MESH] |Th1 Cells/immunology [MESH]Loss of Perp in T Cells Promotes Resistance to Apoptosis of T Helper 1(epmc).pdf DeepDyve Pubget Overpricing