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10.1016/j.rmcr.2018.02.005

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suck abstract from ncbi


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pmid29719809
      Respir+Med+Case+Rep 2018 ; 23 (ä): 167-169
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  • Autoimmune pulmonary alveolar proteinosis in an adolescent successfully treated with inhaled rhGM-CSF (molgramostim) #MMPMID29719809
  • Gajewska ME ; Sritharan SS ; Santoni-Rugiu E ; Bendstrup EM
  • Respir Med Case Rep 2018[]; 23 (ä): 167-169 PMID29719809 show ga
  • Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare parenchymal lung disease characterized by accumulation of surfactant in the airways with high levels of granulocyte-macrophage colony stimulating factor (GM-CSF) antibodies in blood. Disease leads to hypoxemic respiratory failure. Whole lung lavage (WLL) is considered the first line therapy, but procedure can be quite demanding, specifically for children. Recently alternative treatment options with inhaled GM-CSF have been described but no consensus about the standard treatment exists. We here describe a unique case of a 14-year-old patient who was successfully treated with WLL and subsequent inhalations with molgramostim - new recombinant human GM-CSF (rhGM-CSF).
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