Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/ana.25173 http://scihub22266oqcxt.onion/10.1002/ana.25173 C5925521!5925521!29406578     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Neurol 2018 ; 83 (3): 553-61 Nephropedia Template TP {{tp|p=29406578|t=2018. N?methyl?D?aspartate receptor antibody production from germinal center reactions: Therapeutic implications |pdf=|usr=}}{{29406578}} gab.com Text N methyl D aspartate receptor antibody production from germinal center reactions: Therapeutic implications JO: Ann Neurol http://www.kidney.de/pget.php?&tw=1&pmid=29406578 #FOAvip Introduction: N?methyl?D?aspartate receptor (NMDAR) antibody encephalitis is mediated by immunoglobulin G (IgG) autoantibodies directed against the NR1 subunit of the NMDAR. Around 20% of patients have an underlying ovarian teratoma, and the condition responds to early immunotherapies and ovarian teratoma removal. However, despite clear therapeutic relevance, mechanisms of NR1?IgG production and the contribution of germinal center B cells to NR1?IgG levels are unknown. Methods: Clinical data and longitudinal paired serum NR1?reactive IgM and IgG levels from 10 patients with NMDAR?antibody encephalitis were determined. Peripheral blood mononuclear cells from these 10 patients, and two available ovarian teratomas, were stimulated with combinations of immune factors and tested for secretion of total IgG and NR1?specific antibodies. Results: In addition to disease?defining NR1?IgG, serum NR1?IgM was found in 6 of 10 patients. NR1?IgM levels were typically highest around disease onset and detected for several months into the disease course. Moreover, circulating patient B cells were differentiated into CD19+CD27++CD38++ antibody?secreting cells in vitro and, from 90% of patients, secreted NR1?IgM and NR1?IgG. Secreted levels of NR1?IgG correlated with serum NR1?IgG (p?<?0.0001), and this was observed across the varying disease durations, suggestive of an ongoing process. Furthermore, ovarian teratoma tissue contained infiltrating lymphocytes which produced NR1?IgG in culture. Interpretation: Serum NR1?IgM and NR1?IgG, alongside the consistent production of NR1?IgG from circulating B cells and from ovarian teratomas suggest that ongoing germinal center reactions may account for the peripheral cell populations which secrete NR1?IgG. Cells participating in germinal center reactions might be a therapeutic target for the treatment of NMDAR?antibody encephalitis. Ann Neurol 2018;83:553?561 Twit Text FOAVip N methyl D aspartate receptor antibody production from germinal center reactions: Therapeutic implications ????Ann Neurol http://www.kidney.de/pget.php?&tw=1&pmid=29406578 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29406578 #FOAvip English Wikipedia <ref>{{Cite pmid|29406578}}</ref> N?methyl?D?aspartate receptor antibody production from germinal center reactions: Therapeutic implications #MMPMID29406578 Makuch M; Wilson R; Al?Diwani A; Varley J; Kienzler A; Taylor J; Berretta A; Fowler D; Lennox B; Leite MI; Waters P; Irani SR Ann Neurol 2018[Mar]; 83 (3): 553-61 PMID29406578show ga Introduction: N?methyl?D?aspartate receptor (NMDAR) antibody encephalitis is mediated by immunoglobulin G (IgG) autoantibodies directed against the NR1 subunit of the NMDAR. Around 20% of patients have an underlying ovarian teratoma, and the condition responds to early immunotherapies and ovarian teratoma removal. However, despite clear therapeutic relevance, mechanisms of NR1?IgG production and the contribution of germinal center B cells to NR1?IgG levels are unknown. Methods: Clinical data and longitudinal paired serum NR1?reactive IgM and IgG levels from 10 patients with NMDAR?antibody encephalitis were determined. Peripheral blood mononuclear cells from these 10 patients, and two available ovarian teratomas, were stimulated with combinations of immune factors and tested for secretion of total IgG and NR1?specific antibodies. Results: In addition to disease?defining NR1?IgG, serum NR1?IgM was found in 6 of 10 patients. NR1?IgM levels were typically highest around disease onset and detected for several months into the disease course. Moreover, circulating patient B cells were differentiated into CD19+CD27++CD38++ antibody?secreting cells in vitro and, from 90% of patients, secreted NR1?IgM and NR1?IgG. Secreted levels of NR1?IgG correlated with serum NR1?IgG (p? äN?methyl?D?aspartate receptor antibody production from germinal center(epmc).pdf DeepDyve Pubget Overpricing