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2018 ; 9
(ä): 180
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MicroRNA, Proteins, and Metabolites as Novel Biomarkers for Prediabetes,
Diabetes, and Related Complications
#MMPMID29740397
Vaishya S
; Sarwade RD
; Seshadri V
Front Endocrinol (Lausanne)
2018[]; 9
(ä): 180
PMID29740397
show ga
Type 2 diabetes mellitus (T2DM) is no more a lifestyle disease of developed
countries. It has emerged as a major health problem worldwide including
developing countries. However, how diabetes could be detected at an early stage
(prediabetes) to prevent the progression of disease is still unclear. Currently
used biomarkers like glycated hemoglobin and assessment of blood glucose level
have their own limitations. These classical markers can be detected when the
disease is already established. Prognosis of disease at early stages and
prediction of population at a higher risk require identification of specific
markers that are sensitive enough to be detected at early stages of disease.
Biomarkers which could predict the risk of disease in people will be useful for
developing preventive/proactive therapies to those individuals who are at a
higher risk of developing the disease. Recent studies suggested that the
expression of biomolecules including microRNAs, proteins, and metabolites
specifically change during the progression of T2DM and related complications,
suggestive of disease pathology. Owing to their omnipresence in body fluids and
their association with onset, progression, and pathogenesis of T2DM, these
biomolecules can be potential biomarker for prognosis, diagnosis, and management
of disease. In this article, we summarize biomolecules that could be potential
biomarkers and their signature changes associated with T2DM and related
complications during disease pathogenesis.