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2018 ; 9
(ä): 716
Nephropedia Template TP
gab.com Text
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English Wikipedia
The Hunt for the Source of Primary Interleukin-4: How We Discovered That Natural
Killer T Cells and Basophils Determine T Helper Type 2 Cell Differentiation In
Vivo
#MMPMID29740428
Yoshimoto T
Front Immunol
2018[]; 9
(ä): 716
PMID29740428
show ga
Interleukin (IL)-4 plays a central role in determining the phenotype of naïve
CD4(+) T cells by promoting their differentiation into IL-4-producing T helper
type 2 (Th2) cells, which are crucial for the induction of allergic inflammation.
However, to date, the potential sources of "primary IL-4" in vivo, as
distinguished from IL-4 produced by Th2 cells, remain unclear. Here, I describe
the research I carried out in collaboration with Dr. William E. Paul to identify
"primary IL-4"-producing cells and Th2 cell differentiation in vivo.