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10.3389/fimmu.2018.00716

http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00716
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C5924770!5924770 !29740428
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suck abstract from ncbi


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pmid29740428
      Front+Immunol 2018 ; 9 (ä): 716
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  • The Hunt for the Source of Primary Interleukin-4: How We Discovered That Natural Killer T Cells and Basophils Determine T Helper Type 2 Cell Differentiation In Vivo #MMPMID29740428
  • Yoshimoto T
  • Front Immunol 2018[]; 9 (ä): 716 PMID29740428 show ga
  • Interleukin (IL)-4 plays a central role in determining the phenotype of naïve CD4(+) T cells by promoting their differentiation into IL-4-producing T helper type 2 (Th2) cells, which are crucial for the induction of allergic inflammation. However, to date, the potential sources of "primary IL-4" in vivo, as distinguished from IL-4 produced by Th2 cells, remain unclear. Here, I describe the research I carried out in collaboration with Dr. William E. Paul to identify "primary IL-4"-producing cells and Th2 cell differentiation in vivo.
  • |*Cell Differentiation/immunology [MESH]
  • |Animals [MESH]
  • |Antigen-Presenting Cells/immunology/metabolism [MESH]
  • |Basophils/immunology/*metabolism [MESH]
  • |Humans [MESH]
  • |Interleukin-4/genetics/*metabolism [MESH]
  • |Natural Killer T-Cells/immunology/*metabolism [MESH]
  • |T-Lymphocyte Subsets/immunology/metabolism [MESH]


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