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10.3390/genes9040207 http://scihub22266oqcxt.onion/10.3390/genes9040207 C5924549!5924549!29649127     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+(Basel) 2018 ; 9 (4): ä Nephropedia Template TP {{tp|p=29649127|t=2018. Gene Therapy for Chronic HBV?Can We Eliminate cccDNA?|pdf=|usr=}}{{29649127}} gab.com Text Gene Therapy for Chronic HBV Can We Eliminate cccDNA JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29649127 #FOAvip Chronic infection with the hepatitis B virus (HBV) is a global health concern and accounts for approximately 1 million deaths annually. Amongst other limitations of current anti-HBV treatment, failure to eliminate the viral covalently closed circular DNA (cccDNA) and emergence of resistance remain the most worrisome. Viral rebound from latent episomal cccDNA reservoirs occurs following cessation of therapy, patient non-compliance, or the development of escape mutants. Simultaneous viral co-infections, such as by HIV-1, further complicate therapeutic interventions. These challenges have prompted development of novel targeted hepatitis B therapies. Given the ease with which highly specific and potent nucleic acid therapeutics can be rationally designed, gene therapy has generated interest for antiviral application. Gene therapy strategies developed for HBV include gene silencing by harnessing RNA interference, transcriptional inhibition through epigenetic modification of target DNA, genome editing by designer nucleases, and immune modulation with cytokines. DNA-binding domains and effectors based on the zinc finger (ZF), transcription activator-like effector (TALE), and clustered regularly interspaced short palindromic repeat (CRISPR) systems are remarkably well suited to targeting episomal cccDNA. This review discusses recent developments and challenges facing the field of anti-HBV gene therapy, its potential curative significance and the progress towards clinical application. Twit Text FOAVip Gene Therapy for Chronic HBV Can We Eliminate cccDNA ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29649127 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29649127 #FOAvip English Wikipedia <ref>{{Cite pmid|29649127}}</ref> Gene Therapy for Chronic HBV?Can We Eliminate cccDNA? #MMPMID29649127 Bloom K; Maepa MB; Ely A; Arbuthnot P Genes (Basel) 2018[Apr]; 9 (4): ä PMID29649127show ga Chronic infection with the hepatitis B virus (HBV) is a global health concern and accounts for approximately 1 million deaths annually. Amongst other limitations of current anti-HBV treatment, failure to eliminate the viral covalently closed circular DNA (cccDNA) and emergence of resistance remain the most worrisome. Viral rebound from latent episomal cccDNA reservoirs occurs following cessation of therapy, patient non-compliance, or the development of escape mutants. Simultaneous viral co-infections, such as by HIV-1, further complicate therapeutic interventions. These challenges have prompted development of novel targeted hepatitis B therapies. Given the ease with which highly specific and potent nucleic acid therapeutics can be rationally designed, gene therapy has generated interest for antiviral application. Gene therapy strategies developed for HBV include gene silencing by harnessing RNA interference, transcriptional inhibition through epigenetic modification of target DNA, genome editing by designer nucleases, and immune modulation with cytokines. DNA-binding domains and effectors based on the zinc finger (ZF), transcription activator-like effector (TALE), and clustered regularly interspaced short palindromic repeat (CRISPR) systems are remarkably well suited to targeting episomal cccDNA. This review discusses recent developments and challenges facing the field of anti-HBV gene therapy, its potential curative significance and the progress towards clinical application. äGene Therapy for Chronic HBV?Can We Eliminate cccDNA?(epmc).pdf DeepDyve Pubget Overpricing