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2018 ; 10
(4
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
"Appropriate Treatment" and Therapeutic Window in Spasticity Treatment with
IncobotulinumtoxinA: From 100 to 1000 Units
#MMPMID29597251
Ianieri G
; Marvulli R
; Gallo GA
; Fiore P
; Megna M
Toxins (Basel)
2018[Mar]; 10
(4
): ä PMID29597251
show ga
Many neurological diseases (ischemic and hemorrhagic stroke, multiple sclerosis,
infant cerebral palsy, spinal cord injuries, traumatic brain injury, and other
cerebrovascular disorders) may cause muscle spasticity. Different therapeutic
strategies have been proposed for the treatment of spasticity. One of the major
treatments for tone modulation is botulinum toxin type A (BTX-A), performed in
addition to other rehabilitation strategies based on individualized
multidisciplinary programs aimed at achieving certain goals for each patient.
Therapeutic plans must be precisely defined as they must balance the reduction of
spastic hypertonia and retention of residual motor function. To perform and
optimize the treatment, an accurate clinical and instrumental evaluation of
spasticity is needed to determine how this symptom is invalidating and to choose
the best doses, muscles and times of injection in each patient. We introduce an
“appropriate treatment” and no “standard or high dosage
treatment” concept based on our retrospective observational study on 120
patients lasting two years, according to the larger Therapeutic Index and
Therapeutic Window of Incobotulinumtoxin A doses from 100 to 1000 units. We
studied the efficiency and safety of this drug considering the clinical
spasticity significance for specialist physicians and patients.
|Aged
[MESH]
|Botulinum Toxins, Type A/*administration & dosage
[MESH]