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10.1038/s41598-018-25094-4 http://scihub22266oqcxt.onion/10.1038/s41598-018-25094-4 C5923199!5923199!29703903     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29703903|t=2018. IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity |pdf=|usr=}}{{29703903}} gab.com Text IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29703903 #FOAvip IL-31, which is a member of the IL-6 family of cytokines, is produced mainly by activated CD4+ T cells, in particular activated Th2 cells, suggesting a contribution to development of type-2 immune responses. IL-31 was reported to be increased in specimens from patients with atopic dermatitis, and IL-31-transgenic mice develop atopic dermatitis-like skin inflammation, which is involved in the pathogenesis of atopic dermatitis. However, the role of IL-31 in development of contact dermatitis/contact hypersensitivity (CHS), which is mediated by hapten-specific T cells, including Th2 cells, is not fully understood. Therefore, we investigated this using IL-31-deficient (Il31?/?) mice, which we newly generated. We demonstrated that the mice showed normal migration and maturation of skin dendritic cells and induction of hapten-specific T cells in the sensitization phase of FITC-induced CHS, and normal induction of local inflammation in the elicitation phase of FITC- and DNFB-induced CHS. On the other hand, those mice showed reduced scratching frequency and duration during FITC- and/or DNFB-induced CHS. Our findings suggest that IL-31 is responsible for pruritus, but not induction of local skin inflammation, during CHS induced by FITC and DNFB. Twit Text FOAVip IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29703903 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29703903 #FOAvip English Wikipedia <ref>{{Cite pmid|29703903}}</ref> IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity #MMPMID29703903 Takamori A; Nambu A; Sato K; Yamaguchi S; Matsuda K; Numata T; Sugawara T; Yoshizaki T; Arae K; Morita H; Matsumoto K; Sudo K; Okumura K; Kitaura J; Matsuda H; Nakae S Sci Rep 2018[]; 8 (ä): ä PMID29703903show ga IL-31, which is a member of the IL-6 family of cytokines, is produced mainly by activated CD4+ T cells, in particular activated Th2 cells, suggesting a contribution to development of type-2 immune responses. IL-31 was reported to be increased in specimens from patients with atopic dermatitis, and IL-31-transgenic mice develop atopic dermatitis-like skin inflammation, which is involved in the pathogenesis of atopic dermatitis. However, the role of IL-31 in development of contact dermatitis/contact hypersensitivity (CHS), which is mediated by hapten-specific T cells, including Th2 cells, is not fully understood. Therefore, we investigated this using IL-31-deficient (Il31?/?) mice, which we newly generated. We demonstrated that the mice showed normal migration and maturation of skin dendritic cells and induction of hapten-specific T cells in the sensitization phase of FITC-induced CHS, and normal induction of local inflammation in the elicitation phase of FITC- and DNFB-induced CHS. On the other hand, those mice showed reduced scratching frequency and duration during FITC- and/or DNFB-induced CHS. Our findings suggest that IL-31 is responsible for pruritus, but not induction of local skin inflammation, during CHS induced by FITC and DNFB. äIL-31 is crucial for induction of pruritus, but not inflammation, in c(epmc).pdf DeepDyve Pubget Overpricing