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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+Biol
2018 ; 16
(4
): e2005019
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English Wikipedia
Laboratory mouse housing conditions can be improved using common environmental
enrichment without compromising data
#MMPMID29659570
André V
; Gau C
; Scheideler A
; Aguilar-Pimentel JA
; Amarie OV
; Becker L
; Garrett L
; Hans W
; Hölter SM
; Janik D
; Moreth K
; Neff F
; Östereicher M
; Racz I
; Rathkolb B
; Rozman J
; Bekeredjian R
; Graw J
; Klingenspor M
; Klopstock T
; Ollert M
; Schmidt-Weber C
; Wolf E
; Wurst W
; Gailus-Durner V
; Brielmeier M
; Fuchs H
; Hrabé de Angelis M
PLoS Biol
2018[Apr]; 16
(4
): e2005019
PMID29659570
show ga
Animal welfare requires the adequate housing of animals to ensure health and
well-being. The application of environmental enrichment is a way to improve the
well-being of laboratory animals. However, it is important to know whether these
enrichment items can be incorporated in experimental mouse husbandry without
creating a divide between past and future experimental results. Previous
small-scale studies have been inconsistent throughout the literature, and it is
not yet completely understood whether and how enrichment might endanger
comparability of results of scientific experiments. Here, we measured the effect
on means and variability of 164 physiological parameters in 3 conditions: with
nesting material with or without a shelter, comparing these 2 conditions to a
"barren" regime without any enrichments. We studied a total of 360 mice from each
of 2 mouse strains (C57BL/6NTac and DBA/2NCrl) and both sexes for each of the 3
conditions. Our study indicates that enrichment affects the mean values of some
of the 164 parameters with no consistent effects on variability. However, the
influence of enrichment appears negligible compared to the effects of other
influencing factors. Therefore, nesting material and shelters may be used to
improve animal welfare without impairment of experimental outcome or loss of
comparability to previous data collected under barren housing conditions.
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