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10.1186/s13195-018-0371-1 http://scihub22266oqcxt.onion/10.1186/s13195-018-0371-1 C5922310!5922310 !29695305     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29695305 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Alzheimers+Res+Ther 2018 ; 10 (1 ): 43 Nephropedia Template TP {{tp|p=29695305 |t=2018. Cross-sectional associations of plasma vitamin D with cerebral ?-amyloid in older adults at risk of dementia |pdf=|usr=}}{{29695305 }} gab.com Text Cross-sectional associations of plasma vitamin D with cerebral -amyloid in older adults at risk of dementia JO: Alzheimers Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=29695305 #FOAvip BACKGROUND: Vitamin D deficiency is associated with an increased risk of Alzheimer's disease and increased beta-amyloid (A?) in animals. Hence we sought to investigate the relationship between plasma 25-hydroxyvitamin D (25(OH)D) and cerebral A? in older adults with subjective memory complaints. METHODS: This is a secondary analysis of the Multidomain Alzheimer Preventive Trial. Participants were 178 dementia-free individuals aged 70 years or older with data on plasma 25(OH)D and cerebral A? load assessed by [(18)F]-florbetapir positron emission tomography. Plasma 25(OH)D was measured at study baseline using a commercially available electro-chemiluminescence competitive binding assay. Standard uptake value ratios (SUVRs) were generated using the cerebellum as a reference. Brain regions assessed included the cortex, anterior cingulate, anterior putamen, caudate, hippocampus, medial orbitofrontal cortex, occipital cortex, parietal cortex, pons, posterior cingulate, posterior putamen, precuneus, semioval centre and temporal cortex. Associations were explored using fully adjusted multiple linear regression models. RESULTS: Participants had a mean (SD) age of 76.2 years (4.4) and 59.6% were female. The mean (SD) plasma 25(OH)D level was 22.4 ng/ml (10.8) and the mean (SD) cortical SUVR was 1.2 (0.2). We did not find any cross-sectional associations (p?>?0.05) between baseline 25(OH)D levels and A? in any of the brain regions studied. CONCLUSIONS: These preliminary results suggest that circulating 25(OH)D is not associated with cerebral A? in older adults. Further longitudinal studies with the measurement of mid-life vitamin D status are required to explore the relationship between vitamin D and A? accrual over time, thereby circumventing the shortfalls of a cross-sectional study. Twit Text FOAVip Cross-sectional associations of plasma vitamin D with cerebral -amyloid in older adults at risk of dementia ????Alzheimers Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=29695305 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29695305 #FOAvip English Wikipedia <ref>{{Cite pmid|29695305 }}</ref> Cross-sectional associations of plasma vitamin D with cerebral ?-amyloid in older adults at risk of dementia #MMPMID29695305 Nourhashemi F ; Hooper C ; Cantet C ; Féart C ; Gennero I ; Payoux P ; Salabert AS ; Guyonnet S ; De Souto Barreto P ; Vellas B Alzheimers Res Ther 2018[Apr]; 10 (1 ): 43 PMID29695305 show ga BACKGROUND: Vitamin D deficiency is associated with an increased risk of Alzheimer's disease and increased beta-amyloid (A?) in animals. Hence we sought to investigate the relationship between plasma 25-hydroxyvitamin D (25(OH)D) and cerebral A? in older adults with subjective memory complaints. METHODS: This is a secondary analysis of the Multidomain Alzheimer Preventive Trial. Participants were 178 dementia-free individuals aged 70 years or older with data on plasma 25(OH)D and cerebral A? load assessed by [(18)F]-florbetapir positron emission tomography. Plasma 25(OH)D was measured at study baseline using a commercially available electro-chemiluminescence competitive binding assay. Standard uptake value ratios (SUVRs) were generated using the cerebellum as a reference. Brain regions assessed included the cortex, anterior cingulate, anterior putamen, caudate, hippocampus, medial orbitofrontal cortex, occipital cortex, parietal cortex, pons, posterior cingulate, posterior putamen, precuneus, semioval centre and temporal cortex. Associations were explored using fully adjusted multiple linear regression models. RESULTS: Participants had a mean (SD) age of 76.2 years (4.4) and 59.6% were female. The mean (SD) plasma 25(OH)D level was 22.4 ng/ml (10.8) and the mean (SD) cortical SUVR was 1.2 (0.2). We did not find any cross-sectional associations (p?>?0.05) between baseline 25(OH)D levels and A? in any of the brain regions studied. CONCLUSIONS: These preliminary results suggest that circulating 25(OH)D is not associated with cerebral A? in older adults. Further longitudinal studies with the measurement of mid-life vitamin D status are required to explore the relationship between vitamin D and A? accrual over time, thereby circumventing the shortfalls of a cross-sectional study. |Aged [MESH] |Aged, 80 and over [MESH] |Aging/*blood/*pathology [MESH] |Aniline Compounds/metabolism [MESH] |Cerebral Cortex/diagnostic imaging/*metabolism [MESH] |Cross-Sectional Studies [MESH] |Dementia/*diagnosis [MESH] |Ethylene Glycols/metabolism [MESH] |Female [MESH] |Humans [MESH] |Linear Models [MESH] |Male [MESH] |Mental Status and Dementia Tests [MESH] |Positron-Emission Tomography [MESH]Cross-sectional associations of plasma vitamin D with cerebral ?-amylo(epmc).pdf DeepDyve Pubget Overpricing