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10.22203/eCM.v033a12 http://scihub22266oqcxt.onion/10.22203/eCM.v033a12 C5922258!5922258!28217833     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+Cell+Mater 2017 ; 33 (ä): 158-68 Nephropedia Template TP {{tp|p=28217833|t=2017. Lengthening primary cilia enhances cellular mechanosensitivity |pdf=|usr=}}{{28217833}} gab.com Text Lengthening primary cilia enhances cellular mechanosensitivity JO: Eur Cell Mater http://www.kidney.de/pget.php?&tw=1&pmid=28217833 #FOAvip The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and directing intracellular signaling cascades in response to external stimuli. When primary cilia formation is disrupted, cells have diminished mechanosensitivity and an abrogated response to mechanical stimulation. Due to this important role, we hypothesized that increasing primary cilia length would enhance the downstream response, and therefore, mechanosensitivity. To test this hypothesis, we increased osteocyte primary cilia length with fenoldopam and lithium and found that cells with longer primary cilia are more mechanosensitive. Furthermore, fenoldopam treatment potentiated adenylyl cyclase activity and was able to recover primary cilia form and sensitivity in cells with impaired cilia. This work demonstrates that modulating the structure of the primary cilium directly impacts cellular mechanosensitivity. Our results implicate cilium length as a potential therapeutic target for combating numerous conditions characterized by impaired cilia function. Twit Text FOAVip Lengthening primary cilia enhances cellular mechanosensitivity ????Eur Cell Mater http://www.kidney.de/pget.php?&tw=1&pmid=28217833 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28217833 #FOAvip English Wikipedia <ref>{{Cite pmid|28217833}}</ref> Lengthening primary cilia enhances cellular mechanosensitivity #MMPMID28217833 Spasic M; Jacobs CR Eur Cell Mater 2017[Feb]; 33 (ä): 158-68 PMID28217833show ga The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and directing intracellular signaling cascades in response to external stimuli. When primary cilia formation is disrupted, cells have diminished mechanosensitivity and an abrogated response to mechanical stimulation. Due to this important role, we hypothesized that increasing primary cilia length would enhance the downstream response, and therefore, mechanosensitivity. To test this hypothesis, we increased osteocyte primary cilia length with fenoldopam and lithium and found that cells with longer primary cilia are more mechanosensitive. Furthermore, fenoldopam treatment potentiated adenylyl cyclase activity and was able to recover primary cilia form and sensitivity in cells with impaired cilia. This work demonstrates that modulating the structure of the primary cilium directly impacts cellular mechanosensitivity. Our results implicate cilium length as a potential therapeutic target for combating numerous conditions characterized by impaired cilia function. äLengthening primary cilia enhances cellular mechanosensitivity (epmc).pdf DeepDyve Pubget Overpricing