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10.1038/nsmb.3174 http://scihub22266oqcxt.onion/10.1038/nsmb.3174 C5922253!5922253!26878241     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Struct+Mol+Biol 2016 ; 23 (3): 239-47 Nephropedia Template TP {{tp|p=26878241|t=2016. Super-resolution 3D tomography of interactions and competition in the nuclear pore complex |pdf=|usr=}}{{26878241}} gab.com Text Super-resolution 3D tomography of interactions and competition in the nuclear pore complex JO: Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26878241 #FOAvip A selective barrier formed by intrinsically disordered Phe-Gly (FG) nucleoporins (Nups) allows transport receptor (TR)-facilitated translocation of signal-dependent cargos through the nuclear pore complexes (NPCs) of eukaryotic cells. However, the configuration of the FG-Nup barrier and its interactions with multiple TRs in native NPCs remain obscure. Here, we mapped the interaction sites of various TRs or FG segments within the FG-Nup barrier by using high-speed super-resolution microscopy and used these sites to reconstruct the three-dimensional tomography of the native barrier in the NPC. We found that each TR possesses a unique interaction zone within the FG-Nup barrier and that two major TRs, importin ?1 and Crm1, outcompete other TRs in binding FG Nups. Moreover, TRs may alter the tomography of the FG-Nup barrier and affect one another?s pathways under circumstances of heavy competition. Twit Text FOAVip Super-resolution 3D tomography of interactions and competition in the nuclear pore complex ????Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26878241 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26878241 #FOAvip English Wikipedia <ref>{{Cite pmid|26878241}}</ref> Super-resolution 3D tomography of interactions and competition in the nuclear pore complex #MMPMID26878241 Ma J; Goryaynov A; Yang W Nat Struct Mol Biol 2016[Mar]; 23 (3): 239-47 PMID26878241show ga A selective barrier formed by intrinsically disordered Phe-Gly (FG) nucleoporins (Nups) allows transport receptor (TR)-facilitated translocation of signal-dependent cargos through the nuclear pore complexes (NPCs) of eukaryotic cells. However, the configuration of the FG-Nup barrier and its interactions with multiple TRs in native NPCs remain obscure. Here, we mapped the interaction sites of various TRs or FG segments within the FG-Nup barrier by using high-speed super-resolution microscopy and used these sites to reconstruct the three-dimensional tomography of the native barrier in the NPC. We found that each TR possesses a unique interaction zone within the FG-Nup barrier and that two major TRs, importin ?1 and Crm1, outcompete other TRs in binding FG Nups. Moreover, TRs may alter the tomography of the FG-Nup barrier and affect one another?s pathways under circumstances of heavy competition. äSuper-resolution 3D tomography of interactions and competition in the (epmc).pdf DeepDyve Pubget Overpricing