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10.2147/ITT.S163924 http://scihub22266oqcxt.onion/10.2147/ITT.S163924 C5922243!5922243!29719818     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunotargets+Ther 2018 ; 7 (ä): 29-34 Nephropedia Template TP {{tp|p=29719818|t=2018. William Bradley Coley, MD, and the phenomenon of spontaneous regression |pdf=|usr=}}{{29719818}} gab.com Text William Bradley Coley, MD, and the phenomenon of spontaneous regression JO: Immunotargets Ther http://www.kidney.de/pget.php?&tw=1&pmid=29719818 #FOAvip The standard definition of spontaneous regression (SR) of cancer is as follows, ??when a malignant tumor partially or completely disappears without treatment or in the presence of therapy which is considered inadequate to exert a significant influence on neoplastic disease.? SR is also known as Saint Peregrine tumor, the name taken from a young priest, Peregrine Laziosi (1260 [5]?1345, exact date is unknown), who had been diagnosed with a tumor of the tibia. The mass eventually grew so large that it broke through the skin and became severely infected. The available treatment for this condition was limited to amputation. Historical records report that on the day of surgery, physicians found that the tumor had disappeared and reportedly never returned. To date, the medical literature consists only of individual case studies and overviews of this phenomenon. The most cited work on the subject was done by surgeons Tilden Everson and Warren Cole who reviewed 176 published cases of SR from 1900 to 1960. While a percentage of these were found not to be cases of SR, there remained a number of unexplained cases. A frequent theme in many cases of SR is the co-occurrence of infection. Given the current interest in immunotherapy in the treatment of cancer, this article discusses one of the very early pioneers of this theory, William Bradley Coley, MD, a surgeon who was clearly ahead of his time. Ostracized by colleagues for his belief that stimulation of the immune system could in fact produce a regression of cancer, Coley remained convinced that his theory was right and, while he was not familiar with cytokines such as tumor necrosis factor (TNF), interferons, and streptokinase, he knew instinctively that an innate immune response was taking place. Twit Text FOAVip William Bradley Coley, MD, and the phenomenon of spontaneous regression ????Immunotargets Ther http://www.kidney.de/pget.php?&tw=1&pmid=29719818 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29719818 #FOAvip English Wikipedia <ref>{{Cite pmid|29719818}}</ref> William Bradley Coley, MD, and the phenomenon of spontaneous regression #MMPMID29719818 Vernon LF Immunotargets Ther 2018[]; 7 (ä): 29-34 PMID29719818show ga The standard definition of spontaneous regression (SR) of cancer is as follows, ??when a malignant tumor partially or completely disappears without treatment or in the presence of therapy which is considered inadequate to exert a significant influence on neoplastic disease.? SR is also known as Saint Peregrine tumor, the name taken from a young priest, Peregrine Laziosi (1260 [5]?1345, exact date is unknown), who had been diagnosed with a tumor of the tibia. The mass eventually grew so large that it broke through the skin and became severely infected. The available treatment for this condition was limited to amputation. Historical records report that on the day of surgery, physicians found that the tumor had disappeared and reportedly never returned. To date, the medical literature consists only of individual case studies and overviews of this phenomenon. The most cited work on the subject was done by surgeons Tilden Everson and Warren Cole who reviewed 176 published cases of SR from 1900 to 1960. While a percentage of these were found not to be cases of SR, there remained a number of unexplained cases. A frequent theme in many cases of SR is the co-occurrence of infection. Given the current interest in immunotherapy in the treatment of cancer, this article discusses one of the very early pioneers of this theory, William Bradley Coley, MD, a surgeon who was clearly ahead of his time. Ostracized by colleagues for his belief that stimulation of the immune system could in fact produce a regression of cancer, Coley remained convinced that his theory was right and, while he was not familiar with cytokines such as tumor necrosis factor (TNF), interferons, and streptokinase, he knew instinctively that an innate immune response was taking place. äWilliam Bradley Coley, MD, and the phenomenon of spontaneous regressio(epmc).pdf DeepDyve Pubget Overpricing