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10.1111/j.1349-7006.1998.tb00500.x

http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1998.tb00500.x
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C5921695!5921695!9849589
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suck abstract from ncbi


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pmid9849589      Jpn+J+Cancer+Res 1998 ; 89 (10): 1082-6
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  • Elevation of Cytoplasmic Cytochrome c in Radiation?induced Apoptosis #MMPMID9849589
  • Kurihara M; Kurihara H; Tsukuda M
  • Jpn J Cancer Res 1998[Oct]; 89 (10): 1082-6 PMID9849589show ga
  • The signal transduction pathway involved in radiation?induced apoptosis remains unclear, especially as regards the site at which the primary effect of radiation occurs. In this study, we demonstrate that cytochrome c may be released from mitochondria into the cytosol after irradiation, but that direct irradiation of isolated mitochondria induces no elevation of cytochrome c release. These observations suggest that cytochrome c and mitochondria may be involved in the radiation?induced apoptotic pathway, but mitochondria might not be a target of radiation, and that a signal transduction pathway from an unknown target might exist upstream of mitochondria during radiation?induced apoptosis.
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