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10.1186/s12879-018-3100-2 http://scihub22266oqcxt.onion/10.1186/s12879-018-3100-2 C5921543!5921543 !29699503     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29699503 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMC+Infect+Dis 2018 ; 18 (1 ): 194 Nephropedia Template TP {{tp|p=29699503 |t=2018. Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates |pdf=|usr=}}{{29699503 }} gab.com Text Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates JO: BMC Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=29699503 #FOAvip BACKGROUND: Invasive candidiasis differs greatly between children and neonates. We aimed to investigate the different therapeutic approaches and their effects on treatment outcomes of these two groups. METHODS: Episodes of neonatal invasive candidiasis were compared with non-neonatal pediatric episodes during a 12-year cohort study. Clinical isolates were documented by matrix-assisted laser desorption/ionization-time of flight mass spectrometry and DNA sequencing, and antifungal susceptibility testing was performed. RESULTS: A total of 342 episodes of invasive candidiasis (113 neonatal and 229 non-neonatal pediatric episodes) in 281 pediatric patients (96 neonates and 185 children) were identified. Candida albicans was the most common pathogen causing invasive candidiasis in neonates and children (47.8% vs. 44.1%). The antifungal susceptibility profiles were not significantly different between neonates and children. More neonates received amphotericin B as therapy, whereas more children received fluconazole or caspofungin. Compared with children, neonates had a significantly longer duration of fungemia, higher rates of septic shock (34.5% vs. 21.8%; P?=?0.013), sepsis-attributable mortality (28.3% vs. 17.5%; P?=?0.024) and in-hospital mortality (42.7% vs. 25.4%; P?=?0.004) than children. Independent risk factors for treatment failure of invasive candidiasis were septic shock (odds ration [OR] 16.01; 95% confidence interval [CI] 7.64-33.56; P?<? 0.001), delayed removal of intravenous catheter (OR 6.78; 95% CI 2.80-17.41; P?<? 0.001), renal failure (OR 5.38; 95% CI 1.99-14.57; P?=?0.001), and breakthrough invasive candidiasis (OR 2.99; 95% CI 1.04-8.67; P?=?0.043). CONCLUSIONS: Neonatal invasive candidiasis has worse outcomes than non-neonatal pediatric candidiasis. Neonatologists and pediatricians must consider age-specific differences when developing treatment and prevention guidelines, or when interpreting studies of other age groups. Twit Text FOAVip Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates ????BMC Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=29699503 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29699503 #FOAvip English Wikipedia <ref>{{Cite pmid|29699503 }}</ref> Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates #MMPMID29699503 Hsu JF ; Lai MY ; Lee CW ; Chu SM ; Wu IH ; Huang HR ; Lee IT ; Chiang MC ; Fu RH ; Tsai MH BMC Infect Dis 2018[Apr]; 18 (1 ): 194 PMID29699503 show ga BACKGROUND: Invasive candidiasis differs greatly between children and neonates. We aimed to investigate the different therapeutic approaches and their effects on treatment outcomes of these two groups. METHODS: Episodes of neonatal invasive candidiasis were compared with non-neonatal pediatric episodes during a 12-year cohort study. Clinical isolates were documented by matrix-assisted laser desorption/ionization-time of flight mass spectrometry and DNA sequencing, and antifungal susceptibility testing was performed. RESULTS: A total of 342 episodes of invasive candidiasis (113 neonatal and 229 non-neonatal pediatric episodes) in 281 pediatric patients (96 neonates and 185 children) were identified. Candida albicans was the most common pathogen causing invasive candidiasis in neonates and children (47.8% vs. 44.1%). The antifungal susceptibility profiles were not significantly different between neonates and children. More neonates received amphotericin B as therapy, whereas more children received fluconazole or caspofungin. Compared with children, neonates had a significantly longer duration of fungemia, higher rates of septic shock (34.5% vs. 21.8%; P?=?0.013), sepsis-attributable mortality (28.3% vs. 17.5%; P?=?0.024) and in-hospital mortality (42.7% vs. 25.4%; P?=?0.004) than children. Independent risk factors for treatment failure of invasive candidiasis were septic shock (odds ration [OR] 16.01; 95% confidence interval [CI] 7.64-33.56; P? |Adolescent [MESH] |Amphotericin B/therapeutic use [MESH] |Antifungal Agents/*therapeutic use [MESH] |Candida albicans/pathogenicity [MESH] |Candidiasis, Invasive/*drug therapy/*epidemiology/etiology [MESH] |Caspofungin/therapeutic use [MESH] |Child [MESH] |Child, Preschool [MESH] |Cohort Studies [MESH] |Female [MESH] |Fluconazole/therapeutic use [MESH] |Fungemia/drug therapy/epidemiology/*microbiology [MESH] |Hospital Mortality [MESH] |Humans [MESH] |Incidence [MESH] |Infant [MESH] |Infant, Newborn [MESH] |Male [MESH] |Risk Factors [MESH] |Taiwan/epidemiology [MESH]Comparison of the incidence, clinical features and outcomes of invasiv(epmc).pdf DeepDyve Pubget Overpricing