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10.1111/j.1349-7006.1997.tb00318.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1997.tb00318.x C5921286!5921286 !9414660     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=9414660 &cmd=llinks): Failed to open stream: HTTP request failed! 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Regression of metastatic liver tumors in rats treated with angiogenesis inhibitor TNP-470: occurrence of apoptosis and necrosis |pdf=|usr=}}{{9414660 }} gab.com Text Regression of metastatic liver tumors in rats treated with angiogenesis inhibitor TNP-470: occurrence of apoptosis and necrosis JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=9414660 #FOAvip To clarify the mechanism of the reduction of metastatic liver tumors in rats treated with angiogenesis inhibitor TNP-470, the death of tumor cells was examined pathologically and ultrastructurally. Liver metastases were developed by intravenous injection of AH-130 cells. TNP-470 was given subcutaneously after tumor cell injection. Alterations in the size and number of metastatic tumors were examined at various time points, in association with the analysis of cell death pattern. The metastatic nodules were divided into 4 groups according to the morphological patterns of cell death; no cell death, scattered apoptosis, central necrosis, and diffuse necrosis. The number and size of the metastatic tumors at 2 weeks in untreated rats were larger than those in treated rats. The number of tumors in untreated rats decreased, but the tumor size increased. All rats treated with TNP-470 were alive and free from tumors after 4 weeks, whereas all the untreated rats died of liver metastases. The percentages of the tumors with necrosis in untreated rats (61.2% at 2 weeks and 100% at 4 weeks) were significantly higher than that (31.8% at 2 weeks) in treated rats (P < 0.01). The percentage of the tumors containing apoptotic cells in treated rats was significantly higher than that in untreated rats (54.5% vs. 30.6%; P < 0.05). The growth of metastatic tumors without treatment might be faster than the growth of vessels in untreated tumors, resulting in central necrosis due to ischemia. On the other hand, the reduction of metastatic liver tumors treated with TNP-470 might be caused by inhibition of angiogenesis, providing a weak ischemic stimulus which triggers apoptosis, rather than by a direct cytotoxic effect on tumor cells, because previous in vivo experiments demonstrated that TNP-470 affected endothelial cells but not tumor cells. Twit Text FOAVip Regression of metastatic liver tumors in rats treated with angiogenesis inhibitor TNP-470: occurrence of apoptosis and necrosis ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=9414660 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=9414660 #FOAvip English Wikipedia <ref>{{Cite pmid|9414660 }}</ref> Regression of metastatic liver tumors in rats treated with angiogenesis inhibitor TNP-470: occurrence of apoptosis and necrosis #MMPMID9414660 Ahmed MH ; Arai T ; Konno H ; Nahar L ; Tanaka T ; Izumiyama N ; Takubo K ; Nakamura S ; Baba S Jpn J Cancer Res 1997[Oct]; 88 (10 ): 977-81 PMID9414660 show ga To clarify the mechanism of the reduction of metastatic liver tumors in rats treated with angiogenesis inhibitor TNP-470, the death of tumor cells was examined pathologically and ultrastructurally. Liver metastases were developed by intravenous injection of AH-130 cells. TNP-470 was given subcutaneously after tumor cell injection. Alterations in the size and number of metastatic tumors were examined at various time points, in association with the analysis of cell death pattern. The metastatic nodules were divided into 4 groups according to the morphological patterns of cell death; no cell death, scattered apoptosis, central necrosis, and diffuse necrosis. The number and size of the metastatic tumors at 2 weeks in untreated rats were larger than those in treated rats. The number of tumors in untreated rats decreased, but the tumor size increased. All rats treated with TNP-470 were alive and free from tumors after 4 weeks, whereas all the untreated rats died of liver metastases. The percentages of the tumors with necrosis in untreated rats (61.2% at 2 weeks and 100% at 4 weeks) were significantly higher than that (31.8% at 2 weeks) in treated rats (P < 0.01). The percentage of the tumors containing apoptotic cells in treated rats was significantly higher than that in untreated rats (54.5% vs. 30.6%; P < 0.05). The growth of metastatic tumors without treatment might be faster than the growth of vessels in untreated tumors, resulting in central necrosis due to ischemia. On the other hand, the reduction of metastatic liver tumors treated with TNP-470 might be caused by inhibition of angiogenesis, providing a weak ischemic stimulus which triggers apoptosis, rather than by a direct cytotoxic effect on tumor cells, because previous in vivo experiments demonstrated that TNP-470 affected endothelial cells but not tumor cells. |*Apoptosis [MESH] |Animals [MESH] |Antibiotics, Antineoplastic/*therapeutic use [MESH] |Cyclohexanes [MESH] |Liver Neoplasms/blood supply/*pathology/secondary [MESH] |Liver/drug effects/*pathology [MESH] |Male [MESH] |Microscopy, Electron [MESH] |Necrosis [MESH] |Neoplasm Transplantation [MESH] |Neovascularization, Pathologic/*drug therapy/pathology [MESH] |O-(Chloroacetylcarbamoyl)fumagillol [MESH] |Rats [MESH] |Rats, Inbred Strains [MESH] |Remission Induction [MESH] |Sesquiterpenes/*therapeutic use [MESH]Regression of metastatic liver tumors in rats treated with angiogenesi(epmc).pdf DeepDyve Pubget Overpricing