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10.1016/j.neubiorev.2017.01.033 http://scihub22266oqcxt.onion/10.1016/j.neubiorev.2017.01.033 C5921080!5921080!28143763     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurosci+Biobehav+Rev 2017 ; 75 (ä): 22-39 Nephropedia Template TP {{tp|p=28143763|t=2017. Using the shared genetics of dystonia and ataxia to unravel their pathogenesis |pdf=|usr=}}{{28143763}} gab.com Text Using the shared genetics of dystonia and ataxia to unravel their pathogenesis JO: Neurosci Biobehav Rev http://www.kidney.de/pget.php?&tw=1&pmid=28143763 #FOAvip In this review we explore the similarities between spinocerebellar ataxias and dystonias, and suggest potentially shared molecular pathways using a gene co-expression network approach. The spinocerebellar ataxias are a group of neurodegenerative disorders characterized by coordination problems caused mainly by atrophy of the cerebellum. The dystonias are another group of neurological movement disorders linked to basal ganglia dysfunction, although evidence is now pointing to cerebellar involvement as well. Our gene co-expression network approach identified 99 shared genes and showed the involvement of two major pathways: synaptic transmission and neurodevelopment. These pathways overlapped in the two disorders, with a large role for GABAergic signaling in both. The overlapping pathways may provide novel targets for disease therapies. We need to prioritize variants obtained by whole exome sequencing in the genes associated with these pathways in the search for new pathogenic variants, which can than be used to help in the genetic counseling of patients and their families. Twit Text FOAVip Using the shared genetics of dystonia and ataxia to unravel their pathogenesis ????Neurosci Biobehav Rev http://www.kidney.de/pget.php?&tw=1&pmid=28143763 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28143763 #FOAvip English Wikipedia <ref>{{Cite pmid|28143763}}</ref> Using the shared genetics of dystonia and ataxia to unravel their pathogenesis #MMPMID28143763 Nibbeling EA; Delnooz CC; de Koning TJ; Sinke RJ; Jinnah HA; Tijssen MA; Verbeek DS Neurosci Biobehav Rev 2017[Apr]; 75 (ä): 22-39 PMID28143763show ga In this review we explore the similarities between spinocerebellar ataxias and dystonias, and suggest potentially shared molecular pathways using a gene co-expression network approach. The spinocerebellar ataxias are a group of neurodegenerative disorders characterized by coordination problems caused mainly by atrophy of the cerebellum. The dystonias are another group of neurological movement disorders linked to basal ganglia dysfunction, although evidence is now pointing to cerebellar involvement as well. Our gene co-expression network approach identified 99 shared genes and showed the involvement of two major pathways: synaptic transmission and neurodevelopment. These pathways overlapped in the two disorders, with a large role for GABAergic signaling in both. The overlapping pathways may provide novel targets for disease therapies. We need to prioritize variants obtained by whole exome sequencing in the genes associated with these pathways in the search for new pathogenic variants, which can than be used to help in the genetic counseling of patients and their families. äUsing the shared genetics of dystonia and ataxia to unravel their path(epmc).pdf DeepDyve Pubget Overpricing