Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3892/ol.2018.8212 http://scihub22266oqcxt.onion/10.3892/ol.2018.8212 C5920920!5920920!29731883     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2018 ; 15 (5): 7237-42 Nephropedia Template TP {{tp|p=29731883|t=2018. Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer |pdf=|usr=}}{{29731883}} gab.com Text Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29731883 #FOAvip Angiopoietin-1 (Ang1) is a binding partner of endothelial cell-specific tyrosine-protein kinase receptor (Tie2), which serves important roles in vascular development and angiogenesis. Tie2 is closely associated with the metastasis of oral squamous cell carcinomas (OSCCs) however, little is known about the correlation between Tie2 and Ang1. In the present study, the functional mechanisms of the Tie2/Ang1 interaction were investigated using Tie2 overexpressed (oeTie2) OSCC cells and recombinant Ang1 protein. oeTie2 cells had increased cell-cell and cell-extracellular matrix adhesions compared with the control cells. Additionally, the adhesive activities increased following treatment with exogenous Ang1, indicating that Ang1 directly enhances Tie2 functions. In the clinical OSCC data from 10 cases positive for regional lymph node metastasis, all cases were negative for Tie2 expression and eight cases (80%) were negative for Ang1 expression. These results suggest that Tie2 and Ang1 serve important roles in cancer metastasis and may be potential biomarkers and therapeutic targets for OSCC metastasis. Twit Text FOAVip Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29731883 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29731883 #FOAvip English Wikipedia <ref>{{Cite pmid|29731883}}</ref> Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer #MMPMID29731883 Kitajima D; Kasamatsu A; Nakashima D; Miyamoto I; Kimura Y; Endo-Sakamoto Y; Shiiba M; Tanzawa H; Uzawa K Oncol Lett 2018[May]; 15 (5): 7237-42 PMID29731883show ga Angiopoietin-1 (Ang1) is a binding partner of endothelial cell-specific tyrosine-protein kinase receptor (Tie2), which serves important roles in vascular development and angiogenesis. Tie2 is closely associated with the metastasis of oral squamous cell carcinomas (OSCCs) however, little is known about the correlation between Tie2 and Ang1. In the present study, the functional mechanisms of the Tie2/Ang1 interaction were investigated using Tie2 overexpressed (oeTie2) OSCC cells and recombinant Ang1 protein. oeTie2 cells had increased cell-cell and cell-extracellular matrix adhesions compared with the control cells. Additionally, the adhesive activities increased following treatment with exogenous Ang1, indicating that Ang1 directly enhances Tie2 functions. In the clinical OSCC data from 10 cases positive for regional lymph node metastasis, all cases were negative for Tie2 expression and eight cases (80%) were negative for Ang1 expression. These results suggest that Tie2 and Ang1 serve important roles in cancer metastasis and may be potential biomarkers and therapeutic targets for OSCC metastasis. äEvidence for critical role of Tie2/Ang1 interaction in metastatic oral(epmc).pdf DeepDyve Pubget Overpricing