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10.1038/s41413-018-0016-9 http://scihub22266oqcxt.onion/10.1038/s41413-018-0016-9 C5920070!5920070!29736302     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bone+Res 2018 ; 6 (ä): ä Nephropedia Template TP {{tp|p=29736302|t=2018. Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies |pdf=|usr=}}{{29736302}} gab.com Text Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies JO: Bone Res http://www.kidney.de/pget.php?&tw=1&pmid=29736302 #FOAvip Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of RA progress in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of the disease progress. Here we dissect the etiology and pathology at specific stages: (i) triggering, (ii) maturation, (iii) targeting, and (iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences. Modern pharmacologic therapies (including conventional, biological, and novel potential small molecule disease-modifying anti-rheumatic drugs) remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity. Despite this, a significant proportion of RA patients do not effectively respond to the current therapies and thus new drugs are urgently required. This review discusses recent advances of our  understanding of RA pathogenesis, disease modifying drugs, and provides perspectives on next generation therapeutics for RA. Twit Text FOAVip Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies ????Bone Res http://www.kidney.de/pget.php?&tw=1&pmid=29736302 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29736302 #FOAvip English Wikipedia <ref>{{Cite pmid|29736302}}</ref> Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies #MMPMID29736302 Guo Q; Wang Y; Xu D; Nossent J; Pavlos NJ; Xu J Bone Res 2018[]; 6 (ä): ä PMID29736302show ga Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of RA progress in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of the disease progress. Here we dissect the etiology and pathology at specific stages: (i) triggering, (ii) maturation, (iii) targeting, and (iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences. Modern pharmacologic therapies (including conventional, biological, and novel potential small molecule disease-modifying anti-rheumatic drugs) remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity. Despite this, a significant proportion of RA patients do not effectively respond to the current therapies and thus new drugs are urgently required. This review discusses recent advances of our  understanding of RA pathogenesis, disease modifying drugs, and provides perspectives on next generation therapeutics for RA. äRheumatoid arthritis: pathological mechanisms and modern pharmacologic(epmc).pdf DeepDyve Pubget Overpricing