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10.1038/s41467-018-04033-x http://scihub22266oqcxt.onion/10.1038/s41467-018-04033-x C5919970!5919970!29700304     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29700304|t=2018. Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors |pdf=|usr=}}{{29700304}} gab.com Text Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29700304 #FOAvip Altered mitochondrial dynamics can broadly impact tumor cell physiology. Using genetic and pharmacological profiling of cancer cell lines and human tumors, we here establish that perturbations to the mitochondrial dynamics network also result in specific therapeutic vulnerabilities. In particular, through distinct mechanisms, tumors with increased mitochondrial fragmentation or connectivity are hypersensitive to SMAC mimetics, a class of compounds that induce apoptosis through inhibition of IAPs and for which robust sensitivity biomarkers remain to be identified. Further, because driver oncogenes exert dominant control over mitochondrial dynamics, oncogene-targeted therapies can be used to sensitize tumors to SMAC mimetics via their effects on fission/fusion dynamics. Collectively, these data demonstrate that perturbations to the mitochondrial dynamics network induce targetable vulnerabilities across diverse human tumors and, more broadly, suggest that the altered structures, activities, and trafficking of cellular organelles may facilitate additional cancer therapeutic opportunities. Twit Text FOAVip Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29700304 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29700304 #FOAvip English Wikipedia <ref>{{Cite pmid|29700304}}</ref> Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors #MMPMID29700304 Anderson GR; Wardell SE; Cakir M; Yip C; Ahn Yr; Ali M; Yllanes AP; Chao CA; McDonnell DP; Wood KC Nat Commun 2018[]; 9 (ä): ä PMID29700304show ga Altered mitochondrial dynamics can broadly impact tumor cell physiology. Using genetic and pharmacological profiling of cancer cell lines and human tumors, we here establish that perturbations to the mitochondrial dynamics network also result in specific therapeutic vulnerabilities. In particular, through distinct mechanisms, tumors with increased mitochondrial fragmentation or connectivity are hypersensitive to SMAC mimetics, a class of compounds that induce apoptosis through inhibition of IAPs and for which robust sensitivity biomarkers remain to be identified. Further, because driver oncogenes exert dominant control over mitochondrial dynamics, oncogene-targeted therapies can be used to sensitize tumors to SMAC mimetics via their effects on fission/fusion dynamics. Collectively, these data demonstrate that perturbations to the mitochondrial dynamics network induce targetable vulnerabilities across diverse human tumors and, more broadly, suggest that the altered structures, activities, and trafficking of cellular organelles may facilitate additional cancer therapeutic opportunities. äDysregulation of mitochondrial dynamics proteins are a targetable feat(epmc).pdf DeepDyve Pubget Overpricing