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10.2169/internalmedicine.9553-17

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suck abstract from ncbi


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pmid29269659
      Intern+Med 2018 ; 57 (7 ): 1039-1043
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  • Successful Treatment of Rapidly Progressive Unclassifiable Idiopathic Interstitial Pneumonia with Anti-melanoma Differentiation-associated Gene-5 Antibody by Intensive Immunosuppressive Therapy #MMPMID29269659
  • Koga T ; Kaieda S ; Okamoto M ; Masuda K ; Fujimoto K ; Sakamoto S ; Nakamura M ; Tominaga M ; Kawayama T ; Fujimoto K ; Hoshino T ; Ida H
  • Intern Med 2018[Apr]; 57 (7 ): 1039-1043 PMID29269659 show ga
  • We describe a case of a woman who presented with a persistent cough, general fatigue, and a fever. Interstitial lung disease was rapidly progressive and resistant to high-dose steroid therapy. She tested positive for the presence of anti-melanoma differentiation-associated gene 5 (MDA-5) antibody, although she had no skin manifestations of dermatomyositis. She was eventually diagnosed with unclassifiable idiopathic interstitial pneumonia and was successfully treated with intensive immunosuppressive therapy including intravenous cyclophosphamide. To our knowledge, this is the first report of anti-MDA-5 antibody in a patient with idiopathic interstitial pneumonia.
  • |Antibodies/*genetics [MESH]
  • |Cyclophosphamide/*therapeutic use [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Idiopathic Interstitial Pneumonias/complications/diagnostic imaging/*drug therapy [MESH]
  • |Idiopathic Pulmonary Fibrosis/diagnostic imaging/*drug therapy [MESH]
  • |Immunosuppressive Agents/*therapeutic use [MESH]
  • |Melanoma/*genetics/*immunology [MESH]
  • |Middle Aged [MESH]


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  • suck abstract from ncbi

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