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Platypnea-orthodeoxia Syndrome Induced by Multiple Vertebral Compression
Fractures and an Atrial Septal Defect
#MMPMID29269685
Harada K
; Nakagawa K
; Ohtsuka H
; Takaya Y
; Akagi T
; Nakamura K
; Morita H
; Ito H
Intern Med
2018[Apr]; 57
(7
): 971-973
PMID29269685
show ga
Platypnea-orthodeoxia syndrome (POS) is a rare condition that is characterized by
dyspnea and arterial oxygen desaturation, which worsen on standing and which are
relieved by recumbency. We treated an 80-year-old woman with an atrial septal
defect (ASD) who demonstrated POS following thoracic and lumbar vertebral
compression fractures. The surgical closure of the ASD relieved her symptoms. The
etiology might have been multiple compression fractures causing kyphosis and
aortic distortion producing right atrial compression and increased right-to-left
flow through the ASD. POS should be considered in the differential diagnosis of
patients who develop dyspnea after vertebral compression fractures. The careful
assessment of the patient's history and clinical condition helps in the diagnosis
of POS.
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