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10.1111/j.1349-7006.1994.tb02406.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1994.tb02406.x C5919528!5919528!8063617     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Jpn+J+Cancer+Res 1994 ; 85 (6): 633-8 Nephropedia Template TP {{tp|p=8063617|t=1994. Cytotoxicity of Simvastatin to Pancreatic Adenocarcinoma Cells Containing Mutant ras Gene |pdf=|usr=}}{{8063617}} gab.com Text Cytotoxicity of Simvastatin to Pancreatic Adenocarcinoma Cells Containing Mutant ras Gene JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=8063617 #FOAvip Simvastatin (SV), a 3?hydroxy?3?methylglutaryl coenzyme A reductase inhibitor, inhibits the synthesis of mevalonic acid. The dose?dependent (0.1?100 ?g/ml) cytotoxicity of SV towards human (MIAPaCa?2, Panc?1, HPC?1, HPC?3, HPC?4, PK?1, PK?9) and hamster (T2) pancreatic carcinoma cell lines was determined by MTT assay. At up to 20 ?g/ml of SV, the effect was reversible and was restored by 60 ?g/ml mevalonic acid. Point mutation of Ki?ras at codon 12 in each cell line was detected by means of the modified polymerase chain reaction. The concentration of SV necessary to achieve 50% cytotoxicity was about 10 ?g/ml, and at this concentration of SV, DNA synthesis assayed in terms of [3H]thymidine uptake, isoprenylation of p21ras examined by Western blotting and cell progression from G1 to S phase of the cell cycle analyzed by flow cytometry were all inhibited. Isoprenylation inhibitors of p21ras, such as SV, are expected to be useful for the treatment of pancreatic cancer. Twit Text FOAVip Cytotoxicity of Simvastatin to Pancreatic Adenocarcinoma Cells Containing Mutant ras Gene ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=8063617 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8063617 #FOAvip English Wikipedia <ref>{{Cite pmid|8063617}}</ref> Cytotoxicity of Simvastatin to Pancreatic Adenocarcinoma Cells Containing Mutant ras Gene #MMPMID8063617 Ura H; Obara T; Nishino N; Tanno S; Okamura K; Namiki M Jpn J Cancer Res 1994[Jun]; 85 (6): 633-8 PMID8063617show ga Simvastatin (SV), a 3?hydroxy?3?methylglutaryl coenzyme A reductase inhibitor, inhibits the synthesis of mevalonic acid. The dose?dependent (0.1?100 ?g/ml) cytotoxicity of SV towards human (MIAPaCa?2, Panc?1, HPC?1, HPC?3, HPC?4, PK?1, PK?9) and hamster (T2) pancreatic carcinoma cell lines was determined by MTT assay. At up to 20 ?g/ml of SV, the effect was reversible and was restored by 60 ?g/ml mevalonic acid. Point mutation of Ki?ras at codon 12 in each cell line was detected by means of the modified polymerase chain reaction. The concentration of SV necessary to achieve 50% cytotoxicity was about 10 ?g/ml, and at this concentration of SV, DNA synthesis assayed in terms of [3H]thymidine uptake, isoprenylation of p21ras examined by Western blotting and cell progression from G1 to S phase of the cell cycle analyzed by flow cytometry were all inhibited. Isoprenylation inhibitors of p21ras, such as SV, are expected to be useful for the treatment of pancreatic cancer. äCytotoxicity of Simvastatin to Pancreatic Adenocarcinoma Cells Contain(epmc).pdf DeepDyve Pubget Overpricing