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10.1111/j.1349-7006.1993.tb02030.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1993.tb02030.x C5919329!5919329!8340258     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Jpn+J+Cancer+Res 1993 ; 84 (6): 689-96 Nephropedia Template TP {{tp|p=8340258|t=1993. Interferon???producing Tumor Induces Host Tumor?specific T Cell Responses |pdf=|usr=}}{{8340258}} gab.com Text Interferon producing Tumor Induces Host Tumor specific T Cell Responses JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=8340258 #FOAvip We investigated the mechanism of host immune responses against two interferon?? (IFN??) gene?transduced tumors, plasmacytoma MOPC104E(Mu?) and mammary cancer SC115(K?), which originally had weak immunogenicity. Both IFN???producing tumor cells had reduced tumorigenicity and were rejected by syngeneic mice. The rejection was completely blocked by in vivo treatment with anti?CD8 or anti?IFN?? monoclonal antibodies. While anti?CD4 monoclonal antibody also blocked the rejection of SC115(K?), it enhanced the initial tumor growth of MOPC104E(Mu?). Specific protection against subsequent challenge with the respective parental tumor cells was demonstrated in mice which rejected the IFN???producing tumor cells. Cultured lymphocytes derived from immunized mouse spleens had cytotoxic T cell activity against parental tumor cells, as well as against cells that produced IFN??, These findings indicate that the antitumor effects are mediated by cytotoxic T cells and, partly, by helper T cells, and that locally secreted IFN?? plays an important role in generating these effector cells. Twit Text FOAVip Interferon producing Tumor Induces Host Tumor specific T Cell Responses ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=8340258 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8340258 #FOAvip English Wikipedia <ref>{{Cite pmid|8340258}}</ref> Interferon???producing Tumor Induces Host Tumor?specific T Cell Responses #MMPMID8340258 Teramura Y; Watanabe Y; Kan N; Masuda T; Kuribayashi K Jpn J Cancer Res 1993[Jun]; 84 (6): 689-96 PMID8340258show ga We investigated the mechanism of host immune responses against two interferon?? (IFN??) gene?transduced tumors, plasmacytoma MOPC104E(Mu?) and mammary cancer SC115(K?), which originally had weak immunogenicity. Both IFN???producing tumor cells had reduced tumorigenicity and were rejected by syngeneic mice. The rejection was completely blocked by in vivo treatment with anti?CD8 or anti?IFN?? monoclonal antibodies. While anti?CD4 monoclonal antibody also blocked the rejection of SC115(K?), it enhanced the initial tumor growth of MOPC104E(Mu?). Specific protection against subsequent challenge with the respective parental tumor cells was demonstrated in mice which rejected the IFN???producing tumor cells. Cultured lymphocytes derived from immunized mouse spleens had cytotoxic T cell activity against parental tumor cells, as well as against cells that produced IFN??, These findings indicate that the antitumor effects are mediated by cytotoxic T cells and, partly, by helper T cells, and that locally secreted IFN?? plays an important role in generating these effector cells. äInterferon???producing Tumor Induces Host Tumor?specific T Cell Respon(epmc).pdf DeepDyve Pubget Overpricing