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10.1111/j.1349-7006.1993.tb02065.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1993.tb02065.x C5919263!5919263!8407555     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Jpn+J+Cancer+Res 1993 ; 84 (8): 906-13 Nephropedia Template TP {{tp|p=8407555|t=1993. Brefeldin A Blocks the Cytotoxicity of T Cell Receptor ?/? and ?/? Cytotoxic T Lymphocyte Clones Reacting against Human Autologous Cancer Cells |pdf=|usr=}}{{8407555}} gab.com Text Brefeldin A Blocks the Cytotoxicity of T Cell Receptor / and / Cytotoxic T Lymphocyte Clones Reacting against Human Autologous Cancer Cells JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=8407555 #FOAvip We studied the effector mechanism of T cell receptor (TCR) ?/?? and ?/??type cytotoxic T lymphocyte (CTL) clones that react with human autologous tumor cells. Treatment of tumor cells with a fungal antibacterial reagent, brefeldin A (BFA), resulted in the inhibition of cytotoxicity of an autologous tumor (HST?2)?specific CD8+ TCR?/??type CTL, TcHST?2. Other anti?metabolites such as chloroquine, cycloheximide and colchicine did not affect the cytotoxicity. The cell?surface antigen expression, including MHC class I molecules, was not influenced by BFA treatment. Furthermore, BFA did not influence the cytotoxicity of lymphokine?activated killer cells and natural killer cells. Since BFA blocks the transport of peptides from endoplasmic reticulum to the Golgi apparatus, the above data suggest that BFA could affect washing out of the peptide fragments from the MHC class I groove. Consequently, target tumor cells were protected from killing by CTL, Moreover, we obtained a CD4?, 8?, TCR ?/??type (V?1+) CTL clone, TcHOT, that reacts against an autologous ovarial carcinoma, HOT. BFA could also inhibit this cytotoxicity, and it is likely that different presenting molecules other than MHC class I proteins participate in the cytotoxicity of this TCR gm/?? type CTL. These studies suggest that both TCR ?/?? and ?/??type CTL may require antigenic peptides that are most likely derived from the BFA?sensitive, intracellular endogenous target proteins. Twit Text FOAVip Brefeldin A Blocks the Cytotoxicity of T Cell Receptor / and / Cytotoxic T Lymphocyte Clones Reacting against Human Autologous Cancer Cells ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=8407555 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8407555 #FOAvip English Wikipedia <ref>{{Cite pmid|8407555}}</ref> Brefeldin A Blocks the Cytotoxicity of T Cell Receptor ?/? and ?/? Cytotoxic T Lymphocyte Clones Reacting against Human Autologous Cancer Cells #MMPMID8407555 Wada Y; Ikeda H; Ueda D; Ohta M; Takahashi S; Hirata K; Sato N; Kikuchi K Jpn J Cancer Res 1993[Aug]; 84 (8): 906-13 PMID8407555show ga We studied the effector mechanism of T cell receptor (TCR) ?/?? and ?/??type cytotoxic T lymphocyte (CTL) clones that react with human autologous tumor cells. Treatment of tumor cells with a fungal antibacterial reagent, brefeldin A (BFA), resulted in the inhibition of cytotoxicity of an autologous tumor (HST?2)?specific CD8+ TCR?/??type CTL, TcHST?2. Other anti?metabolites such as chloroquine, cycloheximide and colchicine did not affect the cytotoxicity. The cell?surface antigen expression, including MHC class I molecules, was not influenced by BFA treatment. Furthermore, BFA did not influence the cytotoxicity of lymphokine?activated killer cells and natural killer cells. Since BFA blocks the transport of peptides from endoplasmic reticulum to the Golgi apparatus, the above data suggest that BFA could affect washing out of the peptide fragments from the MHC class I groove. Consequently, target tumor cells were protected from killing by CTL, Moreover, we obtained a CD4?, 8?, TCR ?/??type (V?1+) CTL clone, TcHOT, that reacts against an autologous ovarial carcinoma, HOT. BFA could also inhibit this cytotoxicity, and it is likely that different presenting molecules other than MHC class I proteins participate in the cytotoxicity of this TCR gm/?? type CTL. These studies suggest that both TCR ?/?? and ?/??type CTL may require antigenic peptides that are most likely derived from the BFA?sensitive, intracellular endogenous target proteins. äBrefeldin A Blocks the Cytotoxicity of T Cell Receptor ?/? and ?/? Cyt(epmc).pdf DeepDyve Pubget Overpricing