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10.1038/nn.4638 http://scihub22266oqcxt.onion/10.1038/nn.4638 C5919190!5919190!28892058     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28892058&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Neurosci 2017 ; 20 (11): 1520-8 Nephropedia Template TP {{tp|p=28892058|t=2017. Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis |pdf=|usr=}}{{28892058}} gab.com Text Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28892058 #FOAvip Long-range enhancer interactions critically regulate gene expression, yet little is known about how their coordinated activities contribute to CNS development, or how this may in turn relate to disease states. By examining the regulation of the transcription factor NFIA in the developing spinal cord, we identified long-range enhancers that recapitulate NFIA expression across glial and neuronal lineages in vivo. Complementary genetic studies found that Sox9/Brn2 and Isl1/Lhx3 regulate enhancer activity and NFIA expression in glial and neuronal populations. Chromatin conformation analysis (3C) revealed that these enhancers and transcription factors form distinct architectures within these lineages in the spinal cord. In glioma models, the glial-specific architecture is present in tumors, and these enhancers are required for NFIA expression and contribute to glioma formation. By delineating three-dimensional mechanisms of gene expression regulation, our studies identify lineage specific chromatin architectures and associated enhancers that regulate cell fate and tumorigenesis in the CNS. Twit Text FOAVip Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28892058 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28892058 #FOAvip English Wikipedia <ref>{{Cite pmid|28892058}}</ref> Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis #MMPMID28892058 Glasgow SM; Carlson J; Zhu W; Chaboub LS; Kang P; Lee HK; Clovis Y; Lozzi B; McEvilly RJ; Rosenfeld MG; Creighton C; Lee SK; Mohila C; Deneen B Nat Neurosci 2017[Nov]; 20 (11): 1520-8 PMID28892058show ga Long-range enhancer interactions critically regulate gene expression, yet little is known about how their coordinated activities contribute to CNS development, or how this may in turn relate to disease states. By examining the regulation of the transcription factor NFIA in the developing spinal cord, we identified long-range enhancers that recapitulate NFIA expression across glial and neuronal lineages in vivo. Complementary genetic studies found that Sox9/Brn2 and Isl1/Lhx3 regulate enhancer activity and NFIA expression in glial and neuronal populations. Chromatin conformation analysis (3C) revealed that these enhancers and transcription factors form distinct architectures within these lineages in the spinal cord. In glioma models, the glial-specific architecture is present in tumors, and these enhancers are required for NFIA expression and contribute to glioma formation. By delineating three-dimensional mechanisms of gene expression regulation, our studies identify lineage specific chromatin architectures and associated enhancers that regulate cell fate and tumorigenesis in the CNS. äGlia-specific enhancers and chromatin structure regulate NFIA expressi(epmc).pdf DeepDyve Pubget Overpricing