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10.1111/j.1349-7006.1992.tb01985.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1992.tb01985.x C5918946!5918946 !1399818     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\1399818 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Jpn+J+Cancer+Res 1992 ; 83 (8 ): 812-20 Nephropedia Template TP {{tp|p=1399818 |t=1992. Modifying effects of various chemicals on tumor development in a rat wide-spectrum organ carcinogenesis model |pdf=|usr=}}{{1399818 }} gab.com Text Modifying effects of various chemicals on tumor development in a rat wide-spectrum organ carcinogenesis model JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=1399818 #FOAvip The efficacy of a wide-spectrum organ carcinogenesis model for detection of modification potential of exogenous agents was investigated in F344 male rats. Groups of animals were sequentially injected with N-bis(2-hydroxypropyl)nitrosamine (1000 mg/kg body weight, i.p., in saline, twice in week 1), N-ethyl-N-hydroxyethylnitrosamine (1500 mg/kg body weight, i.g., in distilled water, twice in week 2) and 3,2'-dimethyl-4-aminobiphenyl (75 mg/kg body weight, s.c., in corn oil, twice in week 3) for wide-spectrum initiation of target organs and then given one of 10 test chemicals, comprising 6 hepatocarcinogens and 4 non-hepatocarcinogens, for 12 weeks. All 10 chemicals exerted modifying effects in their respective target organs. Enhancing influence could be detected in the liver and urinary bladder with 2-acetylaminofluorene, ethionine, and 3'-methyl-4-dimethylaminoazobenzene; in the liver and thyroid with 4,4'-diaminodiphenylmethane and phenobarbital; in the esophagus and urinary bladder with N-butyl-N-(4-hydroxybutyl)nitrosamine; in the forestomach and urinary bladder with butylated hydroxyanisole; in the liver with 7,12-dimethylbenz[a]anthracene and in the liver and lung with 3-methylcholanthrene. Inhibitory effects on development of glutathione S-transferase placental form-positive liver cell foci were observed with clofibrate. The results indicate that the present model can be reliably utilized as a whole body medium-term bioassay system for assessment of environmental cancer modifiers. Twit Text FOAVip Modifying effects of various chemicals on tumor development in a rat wide-spectrum organ carcinogenesis model ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=1399818 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=1399818 #FOAvip English Wikipedia <ref>{{Cite pmid|1399818 }}</ref> Modifying effects of various chemicals on tumor development in a rat wide-spectrum organ carcinogenesis model #MMPMID1399818 Uwagawa S ; Tsuda H ; Ozaki K ; Takahashi S ; Yamaguchi S ; Mutai M ; Aoki T ; Ito N Jpn J Cancer Res 1992[Aug]; 83 (8 ): 812-20 PMID1399818 show ga The efficacy of a wide-spectrum organ carcinogenesis model for detection of modification potential of exogenous agents was investigated in F344 male rats. Groups of animals were sequentially injected with N-bis(2-hydroxypropyl)nitrosamine (1000 mg/kg body weight, i.p., in saline, twice in week 1), N-ethyl-N-hydroxyethylnitrosamine (1500 mg/kg body weight, i.g., in distilled water, twice in week 2) and 3,2'-dimethyl-4-aminobiphenyl (75 mg/kg body weight, s.c., in corn oil, twice in week 3) for wide-spectrum initiation of target organs and then given one of 10 test chemicals, comprising 6 hepatocarcinogens and 4 non-hepatocarcinogens, for 12 weeks. All 10 chemicals exerted modifying effects in their respective target organs. Enhancing influence could be detected in the liver and urinary bladder with 2-acetylaminofluorene, ethionine, and 3'-methyl-4-dimethylaminoazobenzene; in the liver and thyroid with 4,4'-diaminodiphenylmethane and phenobarbital; in the esophagus and urinary bladder with N-butyl-N-(4-hydroxybutyl)nitrosamine; in the forestomach and urinary bladder with butylated hydroxyanisole; in the liver with 7,12-dimethylbenz[a]anthracene and in the liver and lung with 3-methylcholanthrene. Inhibitory effects on development of glutathione S-transferase placental form-positive liver cell foci were observed with clofibrate. The results indicate that the present model can be reliably utilized as a whole body medium-term bioassay system for assessment of environmental cancer modifiers. |Animals [MESH] |Body Weight/drug effects [MESH] |Carcinogenicity Tests [MESH] |Carcinogens/*toxicity [MESH] |Drinking Behavior/drug effects [MESH] |Esophageal Neoplasms/chemically induced/pathology [MESH] |Feeding Behavior/drug effects [MESH] |Liver Neoplasms, Experimental/chemically induced [MESH] |Liver Neoplasms/chemically induced/pathology [MESH] |Lung Neoplasms/chemically induced/pathology [MESH] |Male [MESH] |Neoplasms, Experimental/*chemically induced/pathology [MESH] |Organ Specificity [MESH] |Rats [MESH] |Rats, Inbred F344 [MESH]Modifying effects of various chemicals on tumor development in a rat (epmc).pdf DeepDyve Pubget Overpricing