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1992 ; 83
(7
): 688-94
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English Wikipedia
Promoting effects of potassium dibasic phosphate on early-stage renal
carcinogenesis in unilaterally nephrectomized rats treated with
N-ethyl-N-hydroxyethylnitrosamine
#MMPMID1517146
Hiasa Y
; Konishi N
; Nakaoka S
; Nakamura T
; Nishii K
; Ohshima M
Jpn J Cancer Res
1992[Jul]; 83
(7
): 688-94
PMID1517146
show ga
The effects of potassium dibasic phosphate (PDP), potassium aluminum sulfate
(PAS) and copper sulfate (CS) on early-stage renal carcinogenesis were
investigated in unilaterally nephrectomized male Wistar rats after
N-ethyl-N-hydroxyethylnitrosamine (EHEN) administration. After feeding 1,000 ppm
EHEN, or basal diet for 2 weeks and removal of the left kidney at week 3, male
Wistar rats were divided into 8 groups of 20 rats each. These groups received the
following dietary treatments: 50,000 ppm PDP, 50,000 ppm PAS, 5,000 ppm CS or
basal diet, respectively, for 18 weeks from weeks 3 to 20. The average numbers of
adenomatous hyperplasias counted as preneoplastic lesions in the EHEN with 50,000
ppm PDP group were significantly higher than in the EHEN alone group or the EHEN
followed by 50,000 ppm PAS or 5,000 ppm CS group. The treatment with 50,000 ppm
PDP induced renal calcification and promoted the development of preneoplastic
lesions in unilaterally nephrectomized rats treated with EHEN, but that with
50,000 ppm PAS or 5,000 ppm CS did not.