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10.1111/j.1349-7006.1992.tb01959.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1992.tb01959.x C5918865!5918865 !1618702     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=1618702 &cmd=llinks): Failed to open stream: HTTP request failed! 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The number of platinum atoms binding to DNA, RNA and protein molecules of HeLa cells treated with cisplatin at its mean lethal concentration |pdf=|usr=}}{{1618702 }} gab.com Text The number of platinum atoms binding to DNA, RNA and protein molecules of HeLa cells treated with cisplatin at its mean lethal concentration JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=1618702 #FOAvip HeLa S-3 cells were treated with 195mPt-radiolabeled cis-diamminedichloroplatinum(II) (CDDP) under various conditions, and the relationship between lethal effect and the number of Pt atoms binding to DNA, RNA and proteins was examined. The mean lethal concentrations for the cells treated with CDDP at 37 degrees C for 1, 2 and 3 h were 2.8, 2.0 and 1.1 microgram/ml, respectively. By using identically treated cells, the number of Pt atoms combined with DNA, RNA and protein molecules were determined after fractionation of the cells using the method of Schneider. In this way, the D0 values given as the drug concentration were substituted for the number of Pt atoms combined with each fraction, then the target volumes expressed as the reciprocals of D0 values were calculated for each fraction. The results provide strong support for the idea that DNA is the primary target for cell killing by CDDP, and the target volumes were 5.17 x 10(4), 5.71 x 10(4) and 1.03 x 10(5) nucleotides for 1, 2 and 3 h treated cells, respectively. Twit Text FOAVip The number of platinum atoms binding to DNA, RNA and protein molecules of HeLa cells treated with cisplatin at its mean lethal concentration ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=1618702 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=1618702 #FOAvip English Wikipedia <ref>{{Cite pmid|1618702 }}</ref> The number of platinum atoms binding to DNA, RNA and protein molecules of HeLa cells treated with cisplatin at its mean lethal concentration #MMPMID1618702 Akaboshi M ; Kawai K ; Maki H ; Akuta K ; Ujeno Y ; Miyahara T Jpn J Cancer Res 1992[May]; 83 (5 ): 522-6 PMID1618702 show ga HeLa S-3 cells were treated with 195mPt-radiolabeled cis-diamminedichloroplatinum(II) (CDDP) under various conditions, and the relationship between lethal effect and the number of Pt atoms binding to DNA, RNA and proteins was examined. The mean lethal concentrations for the cells treated with CDDP at 37 degrees C for 1, 2 and 3 h were 2.8, 2.0 and 1.1 microgram/ml, respectively. By using identically treated cells, the number of Pt atoms combined with DNA, RNA and protein molecules were determined after fractionation of the cells using the method of Schneider. In this way, the D0 values given as the drug concentration were substituted for the number of Pt atoms combined with each fraction, then the target volumes expressed as the reciprocals of D0 values were calculated for each fraction. The results provide strong support for the idea that DNA is the primary target for cell killing by CDDP, and the target volumes were 5.17 x 10(4), 5.71 x 10(4) and 1.03 x 10(5) nucleotides for 1, 2 and 3 h treated cells, respectively. |Cell Survival/drug effects [MESH] |Cisplatin/metabolism/pharmacokinetics/*toxicity [MESH] |DNA, Neoplasm/*metabolism [MESH] |Dose-Response Relationship, Drug [MESH] |HeLa Cells [MESH] |Humans [MESH] |Kinetics [MESH] |Lethal Dose 50 [MESH] |Neoplasm Proteins/*metabolism [MESH] |Platinum/*metabolism/pharmacokinetics [MESH] |RNA, Neoplasm/*metabolism [MESH] |Radioisotopes [MESH]The number of platinum atoms binding to DNA, RNA and protein molecules(epmc).pdf DeepDyve Pubget Overpricing